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Anti-PAG1 Antibody (2D54)

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Catalog No. TMAB-09927

Anti-PAG1 Antibody (2D54) is a Rabbit antibody targeting PAG1. Anti-PAG1 Antibody (2D54) can be used in WB,IHC-P,IHC-Fr,IP,FCM,IF,ICC/IF.

Anti-PAG1 Antibody (2D54)

Anti-PAG1 Antibody (2D54)

😃Good
Catalog No. TMAB-09927
Anti-PAG1 Antibody (2D54) is a Rabbit antibody targeting PAG1. Anti-PAG1 Antibody (2D54) can be used in WB,IHC-P,IHC-Fr,IP,FCM,IF,ICC/IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1507-10 days7-10 days
50 μL$2637-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-PAG1 Antibody (2D54) is a Rabbit antibody targeting PAG1. Anti-PAG1 Antibody (2D54) can be used in WB,IHC-P,IHC-Fr,IP,FCM,IF,ICC/IF.
Ig Type
IgG
Clone
2D54
Reactivity
Human,Mouse,Rat
Application
WB
IHC-P
IHC-Fr
IP
FCM
IF
ICC/IF
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IP: 1:20-50; FCM: 1:50-100; IF: 1:100-500; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCell membrane. Present in lipid rafts.
Tissue SpecificityUbiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundNegatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Antigen Details
Immunogen
A synthesized peptide: human PAG1
Antigen Species
Human
Gene Name
PAG1
Gene ID
55824
Protein Name
phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Uniprot ID
Q9NWQ8
Function
Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Chemical Properties
Molecular WeightTheoretical: 47 kDa. Actual: 80 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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