BAFF/TNFSF13B Protein, Human, Recombinant (CHO)

Name: BAFF/TNFSF13B Protein, Human, Recombinant (CHO)
Brand: TargetMol
SKU: TMPS-00006
Rating: 4.5 (1 reviews)

(Synonyms: ZTNF4, TNFSF20, TNFSF13B, THANK, TALL-1, TALL1, CD257, BLYS, B-cell Activating Factor) Copy Product Info

Synonyms: ZTNF4, TNFSF20, TNFSF13B, THANK, TALL-1, TALL1, CD257, BLYS, B-cell Activating Factor

Catalog No. TMPS-00006 Copy Product Info

BAFF/TNFSF13B Protein, Human, Recombinant (CHO) is expressed in CHO Cells. The accession number is Q9Y275.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$71	7-10 days	7-10 days
10 µg	$113	7-10 days	7-10 days
20 µg	$197	7-10 days	7-10 days
50 µg	$423	7-10 days	7-10 days
100 µg	$698	7-10 days	7-10 days
200 µg	$1,160	7-10 days	7-10 days
500 µg	$2,270	7-10 days	7-10 days
1 mg	$3,790	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	ED 50 < 20.0 ng/ml, determined by dose-dependent mitogenic activity on human RPMI 8226 cells, corresponding to a specific activity of > 5.0 x 10 4 units/mg.
Description	BAFF/TNFSF13B Protein, Human, Recombinant (CHO) is expressed in CHO Cells. The accession number is Q9Y275.
Species	Human
Expression System	CHO Cells
Tag	Tag Free
Accession Number	Q9Y275
Construction	Ala134-Leu285
Protein Purity	> 95% as determined by SDS-PAGE; > 95% as determined by HPLC
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	ZTNF4, TNFSF20, TNFSF13B, THANK, TALL-1, TALL1, CD257, BLYS, B-cell Activating Factor
Research Background	B-cell activating factor, also known as BAFF, TALL-1, TNAK, and zTNF4, is a member of theTNF ligand superfamily designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins lacking a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, resting CD4 + T cells, thymus and peripheral blood leukocytes.

Chemical Properties

Molecular Weight

~17 kDa (Non-reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.