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Anti-CNDP1 Antibody (4P563)
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Catalog No. TMAY-00227
Alias Cn1, carnosine dipeptidase 1 (metallopeptidase M20 family), AI746433
Anti-CNDP1 Antibody (4P563) is a Rabbit antibody targeting CNDP1. Anti-CNDP1 Antibody (4P563) can be used in ELISA,ICC/IF.
Anti-CNDP1 Antibody (4P563)
Anti-CNDP1 Antibody (4P563)
😃Good
Catalog No. TMAY-00227Alias Cn1, carnosine dipeptidase 1 (metallopeptidase M20 family), AI746433
Anti-CNDP1 Antibody (4P563) is a Rabbit antibody targeting CNDP1. Anti-CNDP1 Antibody (4P563) can be used in ELISA,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $94 | 7-10 days | |
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA, ICC/IF Reactivity: Human |
| Alias | Cn1, carnosine dipeptidase 1 (metallopeptidase M20 family), AI746433 |
| Ig Type | Rabbit IgG |
| Clone | 4P563 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of Human CNDP1 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human CNDP1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm. |
| Application | ELISA,ICC/IF |
| Recommended Dose | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CNDP1 (rh CNDP1; TMPY-00719; NP_116038.4; Ser27-His507). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CNDP1, also known as carnosine dipeptidase 1, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protection against the adverse effects of high glucose levels on renal cells. In humans, CNDP1 is secreted from the liver into the serum. In other mammals, including rodents, CNDP1 is expressed exclusively within the kidney and lacks a signal peptide. CNDP1 protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine (β-alanyl-L-histidine), and is identified as human carnosinase expressed in the brain. CNDP1 has been associated with diabetic nephropathy in Europeans and European Americans, but not African-Americans. It was identified and confirmed as a risk factor, were cross-sectional and mostly in patients with type 2 diabetes. The polymorphisms of CNDP1 can be excluded as a risk factor for nephropathy in type 1 diabetes. In addition, CNDP1 is also suggested to be implicated in the actions of neuroprotection and neurotransmiting. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CNDP1 Protein (TMPY-00719) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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