Claudin-18.2 Protein, Human, Recombinant (His)

Name: Claudin-18.2 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-01029
Rating: 4.5 (1 reviews)

(Synonyms: CLDN18, Claudin-18) Copy Product Info

Synonyms: CLDN18, Claudin-18

Catalog No. TMPJ-01029 Copy Product Info

Claudin-18.2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-8xHis tag. The predicted molecular weight is 18 KDa and the accession number is P56856-2.

Pack Size	Price	USA Stock	Global Stock
10 µg	$310	7-10 days	7-10 days
20 µg	$429	7-10 days	7-10 days
50 µg	$669	7-10 days	7-10 days
100 µg	$987	7-10 days	7-10 days
200 µg	$1,550	7-10 days	7-10 days
500 µg	$2,730	7-10 days	7-10 days
1 mg	$4,370	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Claudin-18.2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-8xHis tag. The predicted molecular weight is 18 KDa and the accession number is P56856-2.
Species	Human
Expression System	E. coli
Tag	N-8xHis
Accession Number	P56856-2
Amino Acid	Asp28-Leu76
Construction	Asp28-Leu76
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Supplied as a 0.2 μm filtered solution of 25 mM Tris-HCl, 25 mM NaCl, 0.1% Triton X-100, 10% glycerol, 0.1 mM GSH, 0.01 mM GSSG, pH 8.0.
Synonyms	CLDN18, Claudin-18
Research Background	Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG.

Chemical Properties

Molecular Weight

18 KDa (reducing condition)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.