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L-Homopropargylglycine

Name: L-Homopropargylglycine
Brand: TargetMol
SKU: T15694
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15694Cas No. 98891-36-2

L-Homopropargylglycine is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs[1].

L-Homopropargylglycine

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Purity: 98%

Catalog No. T15694Cas No. 98891-36-2

L-Homopropargylglycine is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs[1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$29	-	In Stock
5 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98%

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COA

Product Introduction

Bioactivity

Description	L-Homopropargylglycine is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs[1].
In vitro	PROTACs consist of two ligands linked together: one targets an E3 ubiquitin ligase, while the other binds to a specific target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade these target proteins[1].

Chemical Properties

Molecular Weight	127.14
Formula	C₆H₉NO₂
Cas No.	98891-36-2
Smiles	N[C@@H](CCC#C)C(O)=O
Relative Density.	1.155 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (786.53 mM), Sonication is recommended.

H2O: 60 mg/mL (471.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (31.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	7.8653 mL	39.3267 mL	78.6535 mL	393.2673 mL
5 mM	1.5731 mL	7.8653 mL	15.7307 mL	78.6535 mL
10 mM	0.7865 mL	3.9327 mL	7.8653 mL	39.3267 mL
20 mM	0.3933 mL	1.9663 mL	3.9327 mL	19.6634 mL
50 mM	0.1573 mL	0.7865 mL	1.5731 mL	7.8653 mL
100 mM	0.0787 mL	0.3933 mL	0.7865 mL	3.9327 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc