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MA-0204

Name: MA-0204
Brand: TargetMol
SKU: T15945
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15945Cas No. 2095128-17-7

MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD).

MA-0204

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Purity: 97.8%

Catalog No. T15945Cas No. 2095128-17-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$88	In Stock	In Stock
5 mg	$188	In Stock	In Stock
10 mg	$317	In Stock	In Stock
25 mg	$515	In Stock	In Stock
50 mg	$713	In Stock	In Stock
100 mg	$948	In Stock	In Stock
200 mg	$1,270	-	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:97.8%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively). It is a potential treatment for Duchene Muscular Dystrophy (DMD).
Targets&IC50	PPARδ:0.4 nM (EC50)(in human), PPARδ:10 nM (EC50)(in rat), PPARδ:7.9 nM (EC50)(in mouse)
In vitro	MA-0204 is >10,000-fold selective for activating PPARδ over PPARα and PPARγ receptors. At concentrations of 1.2-12 nM, MA-0204 enhances fatty acid oxidation in muscle myoblasts from DMD patients in mice, shows high protein binding in mouse plasma, exhibits good permeability, and has low potential for efflux. [C.]
In vivo	In the muscle, PPARδ (30, 100 mg/kg) enhances target gene transcription.

Chemical Properties

Molecular Weight	476.49
Formula	C₂₅H₂₇F₃N₂O₄
Cas No.	2095128-17-7
Smiles	C[C@H](CCCOc1ccccc1Cn1c(C)cnc1-c1ccc(OC(F)(F)F)cc1)CC(O)=O
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (83.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.2 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0987 mL	10.4934 mL	20.9868 mL	104.9340 mL
5 mM	0.4197 mL	2.0987 mL	4.1974 mL	20.9868 mL
10 mM	0.2099 mL	1.0493 mL	2.0987 mL	10.4934 mL
20 mM	0.1049 mL	0.5247 mL	1.0493 mL	5.2467 mL
50 mM	0.0420 mL	0.2099 mL	0.4197 mL	2.0987 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc