HER2-IN-23

Name: HER2-IN-23
Brand: TargetMol
SKU: T213892
Rating: 4.5 (1 reviews)

Catalog No. T213892 Copy Product Info

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HER2-IN-23 is a selective inhibitor of HER2 that reduces total HER2 expression instead of phosphorylated HER2 (p-HER2) levels. It lowers cyclin D1 levels and promotes PARP cleavage. HER2-IN-23 can be utilized in research on HER2-positive breast cancer.

HER2-IN-23

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Catalog No. T213892

HER2-IN-23

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

In vitro

HER2-IN-23 (Compound 4o) exhibits moderate antiproliferative activity against HER2-positive cells, including BT474 (IC50 = 10.5 μM), A431 (IC50 = 9.9 μM), and HCC1954 (IC50 = 8.5 μM), within the concentration range of 0.4-25 μM over 72 hours. However, it shows lower activity against HER2-negative cells like MDA-MB-231 (IC50 = 19.7 μM) and MCF7 (IC50 = 12.8 μM). At a concentration of 1 μM, HER2-IN-23 inhibits the HER2 kinase by 84%, while its effect on other kinases, including EGFR, HER4, and IGF1R, is minimal or non-existent. Furthermore, treatment with HER2-IN-23 at 10 μM for 24 hours significantly reduces total HER2 expression in A431 cells without notably altering phosphorylated HER2 (p-HER2). Cyclin D1 expression is almost completely suppressed, and an increase in PARP cleavage is observed.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc