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Anti-TROP-2 Antibody (5N711)
🥰Excellent
Catalog No. TMAY-03491
Anti-TROP-2 Antibody (5N711) is a Rabbit antibody targeting TROP-2. Anti-TROP-2 Antibody (5N711) can be used in WB,ELISA.
Anti-TROP-2 Antibody (5N711)
Anti-TROP-2 Antibody (5N711)
🥰Excellent
Catalog No. TMAY-03491
Anti-TROP-2 Antibody (5N711) is a Rabbit antibody targeting TROP-2. Anti-TROP-2 Antibody (5N711) can be used in WB,ELISA.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-TROP-2 Antibody (5N711) is a Rabbit antibody targeting TROP-2. Anti-TROP-2 Antibody (5N711) can be used in WB,ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5N711 |
| Reactivity | Mouse, Human, Rat, Rhesus, Cynomolgus |
| Verified Activity | Anti-TROP2 rabbit monoclonal antibody at 1:1000 dilution. -Lane A: A549 Whole Cell Lysate. -Lane B: MCF-7 Whole Cell Lysate. -Lane C: NCI-N87 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:36 kDa. -Observed band size:36-38 kDa(We are unsure as to the identity of these extra bands.) |
| Application | WB,ELISA |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TROP-2 / TACSTD2 (TMPY-02667; Q8BGV3; Met1-Gln270). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse TROP-2 / TACSTD2 protein (TMPY-02667) |
| Antigen Species | Mouse |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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