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11β-Hydroxyandrosterone

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Catalog No. T73780Cas No. 57-61-4

11β-Hydroxyandrosterone is a urinary adrenal-derived androgen metabolite in children with CAH.

11β-Hydroxyandrosterone

11β-Hydroxyandrosterone

😃Good
Catalog No. T73780Cas No. 57-61-4
11β-Hydroxyandrosterone is a urinary adrenal-derived androgen metabolite in children with CAH.
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Product Introduction

Bioactivity
Description
11β-Hydroxyandrosterone is a urinary adrenal-derived androgen metabolite in children with CAH.
In vitro
Among the metabolites of DHEA, AD4, and 11OHAD4, only 11β-Hydroxyandrosterone (a metabolite of 11OHAD4) showed no overlap between C21OHD (classic 21-hydroxylase deficiency) and PORD (cytochrome P450 oxidoreductase deficiency) at a threshold of 0.35 mg/g creatinine. Detection of 11β-Hydroxyandrosterone distinguished the two. [1]
Chemical Properties
Molecular Weight306.44
FormulaC19H30O3
Cas No.57-61-4
SmilesC[C@@]12[C@@]3([C@]([C@]4([C@](C)(C[C@@H]3O)C(=O)CC4)[H])(CC[C@]1(C[C@H](O)CC2)[H])[H])[H]
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (261.06 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2633 mL16.3164 mL32.6328 mL163.1641 mL
5 mM0.6527 mL3.2633 mL6.5266 mL32.6328 mL
10 mM0.3263 mL1.6316 mL3.2633 mL16.3164 mL
20 mM0.1632 mL0.8158 mL1.6316 mL8.1582 mL
50 mM0.0653 mL0.3263 mL0.6527 mL3.2633 mL
100 mM0.0326 mL0.1632 mL0.3263 mL1.6316 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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