This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
MAO A/HSP90-IN-2
Catalog No. T79487 CAS
2927489-99-2
MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90. This compound not only enhances HSP70 expression but also diminishes HER2 and phospho-Akt levels, and downregulates IFN-γ-induced PD-L1 expression in GL26 cells. Demonstrating efficacy against Temozolomide-sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung cancer, and other malignancies, MAO A/HSP90-IN-2 may also impede tumor immune evasion [1].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90. This compound not only enhances HSP70 expression but also diminishes HER2 and phospho-Akt levels, and downregulates IFN-γ-induced PD-L1 expression in GL26 cells. Demonstrating efficacy against Temozolomide-sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung cancer, and other malignancies, MAO A/HSP90-IN-2 may also impede tumor immune evasion [1].
Targets&IC50
HSP90:0.016 μM, MAO-A:4.58 μM
In vitro
MAO A/HSP90-IN-2 inhibits the growth of murine and human glioma cells, as well as colon cancer, leukemia, and non-small cell lung cancer cells (GL26, U251S, U251R, U87MG, U373MG, and LN229, with IC50 values of 0.49, 1.09, 0.26, 0.36, 0.89, and 0.31 μM, respectively) [1]. The compound, at concentrations of 0.3 to 3 μM for 24 hours, upregulates HSP70 expression and downregulates HER2 and phosphorylated AKT expression in GL26 and U251R cells [1]. Additionally, MAO A/HSP90-IN-2, at doses of 0.5 to 1 μM over 24 hours, suppresses the IFN-γ-induced upregulation of PD-L1 in GL26 cells [1].
In vivo
MAO A/HSP90-IN-2 (Compound 4-C) administered at a dose of 25mg/kg via intraperitoneal injection for 8 days demonstrated tumor growth inhibition in the GL26 xenograft tumor model [1].
Molecular Weight
458.98
Formula
C25H31ClN2O4
CAS No.
2927489-99-2
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.