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Leucettine L41

Name: Leucettine L41
Brand: TargetMol
SKU: T24402
Price: 78 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24402Cas No. 1112978-84-3

Alias LeucettineL41

Leucettine L41 (LeucettineL41) is a selective DYRK1A inhibitor that inhibits DYRK2, CLK1, and CLK3, inducing autophagy linked to CLK inhibition. It is used to study Alzheimer's disease and memory deficits.

Leucettine L41

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Purity: 99.08%

Catalog No. T24402Alias LeucettineL41Cas No. 1112978-84-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$78	In Stock	In Stock
2 mg	$113	-	In Stock
5 mg	$189	In Stock	In Stock
10 mg	$355	-	In Stock
25 mg	$588	-	In Stock
50 mg	$838	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.08%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Leucettine L41 (LeucettineL41) is a selective DYRK1A inhibitor that inhibits DYRK2, CLK1, and CLK3, inducing autophagy linked to CLK inhibition. It is used to study Alzheimer's disease and memory deficits.
Targets&IC50	CLK3:4.5 µM, CLK1:0.015 µM, Dyrk2:0.035 µM, Dyrk1A:0.04 µM
In vitro	Leucettine L41 is a potent inhibitor of bispecic tyrosine phosphorylated regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 with IC50 of 0.04, 0.035, 0.015, and 4.5 µM, respectively. Leucettine L41 inhibits phosphorylation of serine/arginine-rich protein (SRp). [1]
In vivo	Leucettine L41(0.4, 1.2, 4 μg) prevented Aβ25-35-induced hippocampal memory impairment and neurotoxicity in mice. [2] Leucettine L41(20 mg/kg, peritoneal injection) AAV-AD rat model showed decreased soluble P-tau form but unchanged soluble Aβ42 level. [4]
Synonyms	LeucettineL41

Chemical Properties

Molecular Weight	307.3
Formula	C₁₇H₁₃N₃O₃
Cas No.	1112978-84-3
Smiles	C(\C=1C=C2C(=CC1)OCO2)=C/3\NC(NC4=CC=CC=C4)=NC3=O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (260.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2541 mL	16.2707 mL	32.5415 mL	162.7075 mL
5 mM	0.6508 mL	3.2541 mL	6.5083 mL	32.5415 mL
10 mM	0.3254 mL	1.6271 mL	3.2541 mL	16.2707 mL
20 mM	0.1627 mL	0.8135 mL	1.6271 mL	8.1354 mL
50 mM	0.0651 mL	0.3254 mL	0.6508 mL	3.2541 mL
100 mM	0.0325 mL	0.1627 mL	0.3254 mL	1.6271 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc