ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc)

Catalog No. TMPJ-00849 Copy Product Info

ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-110 KDa and the accession number is P14719-2.

ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc)

Catalog No. TMPJ-00849

Copy Product Info

ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-110 KDa and the accession number is P14719-2.

Pack Size	Price	USA Stock	Global Stock
5 μg	$72	7-10 days	7-10 days
10 μg	$116	7-10 days	7-10 days
20 μg	$176	7-10 days	7-10 days
50 μg	$310	7-10 days	7-10 days
100 μg	$532	7-10 days	7-10 days
200 μg	$919	7-10 days	7-10 days
500 μg	$1,900	7-10 days	7-10 days
1 mg	$2,730	7-10 days	7-10 days

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In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	1. Loaded Human IL-33 on AR2G Biosensor, can bind Mouse ST2-Fc with an affinity constant of 2.28nM as determined in BLI assay. (Regularly tested) 2. Immobilized Mouse IL-33 at 5μg/ml (100 μl/well) can bind Mouse ST2-Fc. The ED50 of Mouse ST2-Fc is 0.25 ug/ml. (Regularly tested)
Description	ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-110 KDa and the accession number is P14719-2.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	P14719-2
Synonyms	suppression of tumorigenicity 2,ST2V,ST2L,Protein T1,Protein ST2,Lymphocyte antigen 84,Ly84,Interleukin-1 receptor-like 1,IL-33R,IL-1RL1,Il1rl1,IL-1 R4,Fit-1,DER4
Amino Acid	Ser27-Ala337
Construction	Ser27-Ala337 (Val192Ala)
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	90-110 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.