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PVRIG Protein, Mouse, Recombinant (hFc)

Catalog No. TMPJ-00428
Synonyms: MGC138297, transmembrane protein PVRIG, MGC104322, PVRIG, MGC2463, C7orf15MGC138295, C7orf15, CD112R

PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
PVRIG Protein, Mouse, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 86.00
50 μg 5 days $ 262.00
500 μg 5 days $ 2,230.00
1 mg 5 days $ 3,350.00
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Biological Description
Technical Params
Product Properties
Description PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
Species Mouse
Expression System Human Cells
Tag C-Fc
Accession Number A0A1B0GS01
Synonyms MGC138297, transmembrane protein PVRIG, MGC104322, PVRIG, MGC2463, C7orf15MGC138295, C7orf15, CD112R
Amino Acid Ser35-Asp165
Construction Recombinant Mouse Transmembrane Protein PVRIG is produced by our Mammalian expression system and the target gene encoding Ser35-Asp165 is expressed with a human IgG1 Fc tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 48-55 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

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Keywords

PVRIG Protein, Mouse, Recombinant (hFc) MGC138297 transmembrane protein PVRIG MGC104322 C7orf15MGC-138295 PVRIG C7orf15MGC 138295 MGC-2463 MGC2463 C7orf15MGC138295 MGC 138297 MGC-104322 C7orf15 CD112R MGC 104322 MGC-138297 MGC 2463 recombinant recombinant-proteins proteins protein

 

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