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Chlorogenic Acid

Name: Chlorogenic Acid
Brand: TargetMol
SKU: T2805
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2805Cas No. 327-97-9

Alias NSC-407296, Heriguard, 3-O-Caffeoylquinic acid

Chlorogenic acid is a natural phenol found in honeysuckle. Chlorogenic acid has a wide range of biological activities including anti-inflammatory, antioxidant, antitumor, antimicrobial, and neuroprotective.

Chlorogenic Acid

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Purity: 99.67%

Catalog No. T2805Alias NSC-407296, Heriguard, 3-O-Caffeoylquinic acidCas No. 327-97-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Color:White to Gray

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Chlorogenic acid is a natural phenol found in honeysuckle. Chlorogenic acid has a wide range of biological activities including anti-inflammatory, antioxidant, antitumor, antimicrobial, and neuroprotective.
Targets&IC50	Caco-2 cells:758 ± 19.09 µM (EC50), HSV1:15.3 μg/mL (EC50), SW48 cells:353 μM, BALB/3T3 cells:> 280 μM, HCT116 cells:367 μM, HBV DNA:1.2 ± 0.4 μM, HeLa cells:375 μM
In vitro	METHODS: Human colorectal cancer cells Caco-2 were treated with Chlorogenic acid (50-1000 µM) for 24 h and cell viability was measured by MTT assay. RESULTS: Proliferation of Chlorogenic acid-treated cells was significantly reduced, starting at the lowest tested concentration (50 µM), with an EC50 of 758 ± 19.09 µM.[1] METHODS: Mouse mammary carcinoma cells 4T1 were treated with Chlorogenic acid (50-200 µM) for 24 h to enable detection of apoptosis by Flow cytometry. RESULTS: In the early stage, the level of apoptotic cells (Annexin V+/PI-) increased significantly from 1.14% to 0.04%, 34.56%, 40.9% and 37.46% with increasing concentrations of Chlorogenic acid (0, 50, 100, 150 and 200 µM, respectively). Whereas, in the late phase, when the cells were treated with Chlorogenic acid, the apoptotic cell ratio (Annexin V+/PI+) significantly increased from 2.34% to 2.08%, 13.45%, 17.7% and 29.06%, respectively. [2]
In vivo	METHODS: To assess the anti-obesity effects, Chlorogenic acid (150 mg/kg) was administered by gavage to ICR mice on a high-fat diet model (HFD) once daily for six weeks. RESULTS: Administration of Chlorogenic acid significantly promoted weight loss, decreased plasma lipid levels, and altered mRNA expression of genes related to adipogenesis and lipolysis in adipose tissue. [2]
Synonyms	NSC-407296, Heriguard, 3-O-Caffeoylquinic acid

Chemical Properties

Molecular Weight	354.31
Formula	C₁₆H₁₈O₉
Cas No.	327-97-9
Smiles	O(C(C=CC1=CC(O)=C(O)C=C1)=O)[C@@H]2C[C@@](C(O)=O)(O)C[C@@H](O)[C@H]2O
Relative Density.	1.3594 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 66 mg/mL (186.28 mM), Sonication is recommended.

DMSO: 237 mg/mL (668.91 mM), Sonication is recommended.

H2O: 10 mg/mL (28.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8224 mL	14.1119 mL	28.2239 mL	141.1194 mL
5 mM	0.5645 mL	2.8224 mL	5.6448 mL	28.2239 mL
10 mM	0.2822 mL	1.4112 mL	2.8224 mL	14.1119 mL
20 mM	0.1411 mL	0.7056 mL	1.4112 mL	7.0560 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0564 mL	0.2822 mL	0.5645 mL	2.8224 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4112 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc