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Anti-DDR2 Antibody (1R524)
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Catalog No. TMAY-03350
Alias TYRO10, TKT, NTRKR3, MIG20a, discoidin domain receptor tyrosine kinase 2, CD167
Anti-DDR2 Antibody (1R524) is a Rabbit antibody targeting DDR2. Anti-DDR2 Antibody (1R524) can be used in ELISA.
Anti-DDR2 Antibody (1R524)
Anti-DDR2 Antibody (1R524)
😃Good
Catalog No. TMAY-03350Alias TYRO10, TKT, NTRKR3, MIG20a, discoidin domain receptor tyrosine kinase 2, CD167
Anti-DDR2 Antibody (1R524) is a Rabbit antibody targeting DDR2. Anti-DDR2 Antibody (1R524) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $94 | 7-10 days | |
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Mouse |
| Alias | TYRO10, TKT, NTRKR3, MIG20a, discoidin domain receptor tyrosine kinase 2, CD167 |
| Ig Type | Rabbit IgG |
| Clone | 1R524 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse DDR2 / CD167b (rM DDR2 / CD167b; TMPY-01728; NP_072075.2; Met1-Arg399). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse DDR2 / CD167b Protein (TMPY-01728) |
| Antigen Species | Mouse |
| Biology Area | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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