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Cephalotaxine

Name: Cephalotaxine
Brand: TargetMol
SKU: T3366
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3366Cas No. 24316-19-6

Alias ZINC19795976, Cephalotaxlen, (-)-Cephalotaxine

Cephalotaxine (ZINC19795976) is an antiviral and an antitumor agent.

Cephalotaxine

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Purity: 99.15%

Catalog No. T3366Alias ZINC19795976, Cephalotaxlen, (-)-CephalotaxineCas No. 24316-19-6

Cephalotaxine (ZINC19795976) is an antiviral and an antitumor agent.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$34	In Stock	In Stock
50 mg	$47	In Stock	In Stock
100 mg	$68	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.15%

Color:White

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Product Introduction

Cephalotaxine AI Summary

Cephalotaxine inhibits protein synthesis in cell-free lysates with an IC50 value of 440,000,000 nM. It also inhibits anisomycin-induced p38 phosphorylation in human U937 cells with an IC50 of 200 nM and exhibits inhibition of JAK-mediated interferon-gamma-induced Stat1 phosphorylation by more than 65% at 20 μM, while its inhibition of JAK-mediated GM-CSF-induced Stat5 phosphorylation is only 25% at the same concentration. Additionally, Cephalotaxine shows high inhibitory effects on sodium fluorescein uptake in both OATP1B1-transfected and OATP1B3-transfected CHO cells, with inhibition rates of 77.26% and 77.89%, respectively, at 10 μM. It demonstrates bioactivity as an inhibitor of binding or entry into cells for the Marburg Virus with a potency of 6309.6 nM and shows antiproliferative activity against human HL60 cells with an IC50 of 61200 nM after 62 hours, based on the MTS assay. Furthermore, it exhibits antiproliferative activity against human K562, HL-60, and U-937 cells, with an IC50 value greater than 30000 nM for all three cell lines after 72 hours of treatment, indicating moderate to weak inhibitory potency..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cephalotaxine (ZINC19795976) is an antiviral and an antitumor agent.
Synonyms	ZINC19795976, Cephalotaxlen, (-)-Cephalotaxine

Chemical Properties

Molecular Weight	315.36
Formula	C₁₈H₂₁NO₄
Cas No.	24316-19-6
Smiles	COC1=C[C@]23CCCN2CCc2cc4OCOc4cc2[C@@H]3[C@@H]1O
Relative Density.	1.38 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 47 mg/mL (149.04 mM), Sonication is recommended.

Chloroform: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1710 mL	15.8549 mL	31.7098 mL	158.5490 mL
5 mM	0.6342 mL	3.1710 mL	6.3420 mL	31.7098 mL
10 mM	0.3171 mL	1.5855 mL	3.1710 mL	15.8549 mL
20 mM	0.1585 mL	0.7927 mL	1.5855 mL	7.9274 mL
50 mM	0.0634 mL	0.3171 mL	0.6342 mL	3.1710 mL
100 mM	0.0317 mL	0.1585 mL	0.3171 mL	1.5855 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc