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PTP1B-IN-3
🥰Excellent
Catalog No. T12577Cas No. 809272-64-8
PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes.
PTP1B-IN-3
🥰Excellent
Purity: 99.97%
Catalog No. T12577Cas No. 809272-64-8
PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $289 | In Stock | |
| 5 mg | $818 | In Stock | |
| 10 mg | $1,080 | In Stock | |
| 25 mg | $1,460 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,500 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.97%
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Product Introduction
Bioactivity
Chemical Properties
| Description | PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes. |
| Targets&IC50 | PTP1B:120 nM, TCPTP:120 nM |
| In vivo | In NDL2 Ptpn1 transgenic mice, oral administration of PTP1B-IN-3 (compound 3g) at a dose of 30 mg/kg for 21 days significantly delayed the onset of tumor development in NDL2 Ptpn1+/+ mice, extending the median tumor-free days (T50) from 28 days to 75 days [2].In diet-induced obese (DIO) mice, PTP1B-IN-3 (compound 3g) exhibits good oral bioavailability (F of 24%), slow clearance (CL of 0.71 mL/kg/min), and excellent elimination half-life (t1/2 of 6 hours)[2]. |
| Molecular Weight | 362.06 |
| Formula | C12H7BrF2NO3P |
| Cas No. | 809272-64-8 |
| Smiles | N#CC=1C=CC2=CC(Br)=C(C=C2C1)C(F)(F)P(=O)(O)O |
| Relative Density. | 1.86 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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