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Anti-SHOC2 Polyclonal Antibody

Catalog No. TMAB-12778 Copy Product Info
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Anti-SHOC2 Polyclonal Antibody is a Rabbit antibody targeting SHOC2. Anti-SHOC2 Polyclonal Antibody can be used in WB,ELISA,ICC/IF.

Anti-SHOC2 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-12778

Anti-SHOC2 Polyclonal Antibody is a Rabbit antibody targeting SHOC2. Anti-SHOC2 Polyclonal Antibody can be used in WB,ELISA,ICC/IF.

Anti-SHOC2 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2237-10 days7-10 days
100 μL$3727-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-SHOC2 Polyclonal Antibody is a Rabbit antibody targeting SHOC2. Anti-SHOC2 Polyclonal Antibody can be used in WB,ELISA,ICC/IF.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Verified Activity
Sample:
Lane 1: Cerebrum (Mouse) Lysate at 40 μg
Lane 2: Testis (Mouse) Lysate at 40 μg
Lane 3: Esophagus (Mouse) Lysate at 40 μg
Lane 4: Large intestine (Mouse) Lysate at 40 μg
Lane 5: NIH/3T3 (Mouse) Cell Lysate at 30 μg
Lane 6: Cerebrum (Rat) Lysate at 40 μg
Lane 7: Testis (Rat) Lysate at 40 μg
Lane 8: Esophagus (Rat) Lysate at 40 μg
Lane 9: Large intestine (Rat) Lysate at 40 μg
Lane 10: A549 (Human) Cell Lysate at 30 μg
Lane 11: U937 (Human) Cell Lysate at 30 μg
Lane 12: HL60 (Human) Cell Lysate at 30 μg
Primary: Anti-SHOC2 (TMAB-12778) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 62 kD
Observed band size: 60 kD
Application
Recommended Dose
WB: 1:500-2000; ELISA: 1:5000-10000; ICC/IF: 1:50 - 1:100
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundRegulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human SHOC2/Sur8
Antigen Species
Human
Gene Name
SHOC2
Gene ID
Protein Name
Leucine-rich repeat protein SHOC-2
Uniprot ID
Function
Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
Chemical Properties
Molecular WeightTheoretical: 65 kDa. Actual: 60 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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