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Anti-SHOC2 Polyclonal Antibody
😃Good
Catalog No. TMAB-12778
Anti-SHOC2 Polyclonal Antibody is a Rabbit antibody targeting SHOC2. Anti-SHOC2 Polyclonal Antibody can be used in WB,ELISA,ICC/IF.
Anti-SHOC2 Polyclonal Antibody
Anti-SHOC2 Polyclonal Antibody
😃Good
Catalog No. TMAB-12778
Anti-SHOC2 Polyclonal Antibody is a Rabbit antibody targeting SHOC2. Anti-SHOC2 Polyclonal Antibody can be used in WB,ELISA,ICC/IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-SHOC2 Polyclonal Antibody is a Rabbit antibody targeting SHOC2. Anti-SHOC2 Polyclonal Antibody can be used in WB,ELISA,ICC/IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; ELISA: 1:5000-10000; ICC/IF: 1:50 - 1:100 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair. |
| Immunogen | KLH conjugated synthetic peptide: human SHOC2/Sur8 |
| Antigen Species | Human |
| Gene Name | SHOC2 |
| Gene ID | |
| Protein Name | Leucine-rich repeat protein SHOC-2 |
| Uniprot ID | |
| Function | Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. |
| Molecular Weight | Theoretical: 65 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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