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Fumitremorgin C

Name: Fumitremorgin C
Brand: TargetMol
SKU: T15355
Rating: 4.5 (1 reviews)

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Catalog No. T15355Cas No. 118974-02-0

Alias 12α-Fumitremorgin C

Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.

Fumitremorgin C

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Catalog No. T15355Alias 12α-Fumitremorgin CCas No. 118974-02-0

Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
250 μg	$530	35 days	35 days
1 mg	$1,360	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.
In vitro	Multidrug resistance (MDR) presents a significant challenge in cancer chemotherapy, but Fumitremorgin C has shown remarkable efficacy in counteracting this problem by increasing drug accumulation in multidrug-selected cell lines. Specifically, it enhances the effectiveness of doxorubicin, mitoxantrone, and topotecan by reversing mitoxantrone resistance up to 114-fold and doxorubicin resistance 3-fold in MCF-7/mtxR cells. Additionally, in S1M1-3.2 cells, Fumitremorgin C substantially boosts the toxicity of these drugs, demonstrating a 26-fold increase for doxorubicin, 93-fold for mitoxantrone, and 24-fold for topotecan. However, it does not mitigate drug resistance in cells with high levels of Pgp or MRP expression [1]. Notably, Fumitremorgin C virtually eliminates resistance mediated by BCRP in vitro, making it a valuable pharmacological tool for investigating the expression and molecular functionality of this transporter. Furthermore, it significantly raises the toxicity of mitoxantrone and topotecan in vector-transfected MCF-7 cells by 2.5–5.6 fold and reduces the IC50 of topotecan in BCRP-overexpressing cells to levels even lower than those in untreated vector-transfected cells [2].
Synonyms	12α-Fumitremorgin C

Chemical Properties

Molecular Weight	379.45
Formula	C₂₂H₂₅N₃O₃
Cas No.	118974-02-0
Smiles	[H][C@@]12CCCN1C(=O)[C@]1([H])Cc3c([nH]c4cc(OC)ccc34)[C@]([H])(C=C(C)C)N1C2=O
Relative Density.	1.34g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (131.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (8.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6354 mL	13.1770 mL	26.3539 mL	131.7697 mL
5 mM	0.5271 mL	2.6354 mL	5.2708 mL	26.3539 mL
10 mM	0.2635 mL	1.3177 mL	2.6354 mL	13.1770 mL
20 mM	0.1318 mL	0.6588 mL	1.3177 mL	6.5885 mL
50 mM	0.0527 mL	0.2635 mL	0.5271 mL	2.6354 mL
100 mM	0.0264 mL	0.1318 mL	0.2635 mL	1.3177 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc