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Fumitremorgin C

Name: Fumitremorgin C
Brand: TargetMol
SKU: T15355
Rating: 4.5 (1 reviews)

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Catalog No. T15355Cas No. 118974-02-0

Alias 12α-Fumitremorgin C

Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.

Fumitremorgin C

😃Good

Catalog No. T15355Alias 12α-Fumitremorgin CCas No. 118974-02-0

Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
250 μg	$530	35 days	35 days
1 mg	$1,360	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Fumitremorgin C (12α-Fumitremorgin C) is a mycotoxin and inhibits ABCG2/BRCP.
In vitro	Multidrug resistance (MDR) presents a significant challenge in cancer chemotherapy, but Fumitremorgin C has shown remarkable efficacy in counteracting this problem by increasing drug accumulation in multidrug-selected cell lines. Specifically, it enhances the effectiveness of doxorubicin, mitoxantrone, and topotecan by reversing mitoxantrone resistance up to 114-fold and doxorubicin resistance 3-fold in MCF-7/mtxR cells. Additionally, in S1M1-3.2 cells, Fumitremorgin C substantially boosts the toxicity of these drugs, demonstrating a 26-fold increase for doxorubicin, 93-fold for mitoxantrone, and 24-fold for topotecan. However, it does not mitigate drug resistance in cells with high levels of Pgp or MRP expression [1]. Notably, Fumitremorgin C virtually eliminates resistance mediated by BCRP in vitro, making it a valuable pharmacological tool for investigating the expression and molecular functionality of this transporter. Furthermore, it significantly raises the toxicity of mitoxantrone and topotecan in vector-transfected MCF-7 cells by 2.5–5.6 fold and reduces the IC50 of topotecan in BCRP-overexpressing cells to levels even lower than those in untreated vector-transfected cells [2].
Synonyms	12α-Fumitremorgin C

Chemical Properties

Molecular Weight	379.45
Formula	C₂₂H₂₅N₃O₃
Cas No.	118974-02-0
Smiles	[H][C@@]12CCCN1C(=O)[C@]1([H])Cc3c([nH]c4cc(OC)ccc34)[C@]([H])(C=C(C)C)N1C2=O
Relative Density.	1.34g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (131.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (8.7 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6354 mL	13.1770 mL	26.3539 mL	131.7697 mL
5 mM	0.5271 mL	2.6354 mL	5.2708 mL	26.3539 mL
10 mM	0.2635 mL	1.3177 mL	2.6354 mL	13.1770 mL
20 mM	0.1318 mL	0.6588 mL	1.3177 mL	6.5885 mL
50 mM	0.0527 mL	0.2635 mL	0.5271 mL	2.6354 mL
100 mM	0.0264 mL	0.1318 mL	0.2635 mL	1.3177 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc