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5-Fluoromethylornithine dihydrochloride

Name: 5-Fluoromethylornithine dihydrochloride
Brand: TargetMol
SKU: T78197
Price: 142 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78197Cas No. 124796-41-4

Alias 5-FMOrn dihydrochloride

5-Fluoromethylornithine dihydrochloride (5-FMOrn dihydrochloride) is a selective inhibitor of L-Ornithine:2-oxoacid aminotransferase (OAT) and a specific inactivator of OAT, which can be used to study metabolic diseases and neurological diseases.

5-Fluoromethylornithine dihydrochloride

🥰Excellent

Catalog No. T78197Alias 5-FMOrn dihydrochlorideCas No. 124796-41-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$142	In Stock	In Stock
5 mg	$355	In Stock	In Stock
10 mg	$528	-	In Stock
25 mg	$855	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	5-Fluoromethylornithine dihydrochloride (5-FMOrn dihydrochloride) is a selective inhibitor of L-Ornithine:2-oxoacid aminotransferase (OAT) and a specific inactivator of OAT, which can be used to study metabolic diseases and neurological diseases.
In vitro	Incubation for 1 h of L-ornithine carbamoyltransferase, ODC and GABA-T preparations with up to 10 mM 5-Fluoromethylornithine and subsequent determination of the residual enzyme activity demonstrated that none of these enzymes was inactivated. 5-Fluoromethylornithine is a poor substrate of ODC; at 10 mM 5-Fluoromethylornithine, 0.04 nmol of 1-fluoromethylputrescine was formed/h per mg of protein. [1]
In vivo	After intraperitoneal administration of 10 mg of 5-Fluoromethylornithine /kg, there is a rapid decrease of OAT activity in all organs, to a basal value. The time-dependence of the effect of 5-Fluoromethylornithine in brain. Minimum activity was usually observed between 2 and 24 h after 5-Fluoromethylornithine administration, thereafter OAT activity recovered gradually. [1]
Synonyms	5-FMOrn dihydrochloride

Chemical Properties

Molecular Weight	237.1
Formula	C₆H₁₅Cl₂FN₂O₂
Cas No.	124796-41-4
Smiles	O=C(C(CCC(CF)N)N)O.Cl.Cl

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (337.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.2176 mL	21.0881 mL	42.1763 mL	210.8815 mL
5 mM	0.8435 mL	4.2176 mL	8.4353 mL	42.1763 mL
10 mM	0.4218 mL	2.1088 mL	4.2176 mL	21.0881 mL
20 mM	0.2109 mL	1.0544 mL	2.1088 mL	10.5441 mL
50 mM	0.0844 mL	0.4218 mL	0.8435 mL	4.2176 mL
100 mM	0.0422 mL	0.2109 mL	0.4218 mL	2.1088 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OAT5-FMOrn5-Fluoromethylornithine Dihydrochloride5-Fluoromethylornithine

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