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WAY-605471

Name: WAY-605471
Brand: TargetMol
SKU: T9822
Price: 70 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9822Cas No. 378223-81-5

WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.

WAY-605471

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Purity: 99.62%

Catalog No. T9822Cas No. 378223-81-5

WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$70	-	In Stock
5 mg	$161	-	In Stock
10 mg	$237	-	In Stock
25 mg	$355	-	In Stock
50 mg	$497	-	In Stock
100 mg	$678	-	In Stock
1 mL x 10 mM (in DMSO)	$157	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.62%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

WAY-605471 AI Summary

WAY-605471 exhibits a diverse range of bioactivities across various biological systems. Notably, it increases the expression of NF-kB in Human Neuronal Cells with an EC50 of 952.0 nM and activates STAT1 with an EC50 of 233.0 nM. In addition, it modulates miRNAs, particularly activating miR-21 with a potency of 369.0 nM, and activates the Rab9 Promoter with a potency of 562.3 nM. The compound enhances SMN2 Splice Variant Expression with a potency of 6309.6 nM and inhibits multiple viral activities including Hepatitis C Virus at 10000.0 nM and Foot and Mouth Disease Virus at 891.3 nM. It also shows antiviral potential against SARS-CoV-2 by demonstrating a 21.04% inhibition of 3CL-Pro protease activity at 20 µM and inhibiting cytotoxicity in VERO-6 cells. Furthermore, WAY-605471 inhibits various enzymes and transcriptional activities, such as ROR gamma with a potency of 158.5 nM, and demonstrates potential in inhibiting protein interactions and DNA repair mechanisms. The compound also inhibits Tau Fibril Formation and diverse cellular activities in Drosophila S3 cells, Leukemia models, and other human cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

WAY-605471 is a AHR antagonist with IC50 of 0.5 - 1 μM.

Chemical Properties

Molecular Weight	309.4
Formula	C₁₄H₁₅NO₃S₂
Cas No.	378223-81-5
Smiles	N(C(=O)C1=C(C)C=CS1)C=2SC(C(OCC)=O)=C(C)C2
Relative Density.	1.321 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (177.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2321 mL	16.1603 mL	32.3206 mL	161.6031 mL
5 mM	0.6464 mL	3.2321 mL	6.4641 mL	32.3206 mL
10 mM	0.3232 mL	1.6160 mL	3.2321 mL	16.1603 mL
20 mM	0.1616 mL	0.8080 mL	1.6160 mL	8.0802 mL
50 mM	0.0646 mL	0.3232 mL	0.6464 mL	3.2321 mL
100 mM	0.0323 mL	0.1616 mL	0.3232 mL	1.6160 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc