AK-2292

Name: AK-2292
Brand: TargetMol
SKU: T74749
Rating: 4.5 (1 reviews)

(Synonyms: AK2292, AK 2292) Copy Product Info

🥰Excellent

Synonyms: AK2292, AK 2292

Catalog No. T74749 Copy Product Info

🥰Excellent

AK-2292 is a highly potent and selective STAT5A/B PROTAC protein degrader with a DC50 value of 0.10 μM that induces STAT5A/B protein degradation both in vitro and in vivo. AK-2292 can be used in research on acute myeloid leukemia and chronic myeloid leukemia.

Cas No. 2984506-77-4

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

Product Introduction

Bioactivity

Description	AK-2292 is a highly potent and selective STAT5A/B PROTAC protein degrader with a DC50 value of 0.10 μM that induces STAT5A/B protein degradation both in vitro and in vivo. AK-2292 can be used in research on acute myeloid leukemia and chronic myeloid leukemia.
Targets & IC50	STAT5:0.10 μM (DC50)
Synonyms	AK2292, AK 2292

Chemical Properties

Molecular Weight	1070.13
Formula	C₅₂H₅₄F₂N₇O₁₀PS₂
Cas No.	2984506-77-4
Smiles	C(#CCCCN(C(CCN(C(=O)[C@H]1N(C([C@@H](NC(=O)C2=CC=3C(S2)=CC=C(C(P(=O)(O)O)(F)F)C3)[C@@](C)(C)C)=O)CCC1)C4=CC=C(C=C4)C5=NC=CS5)=O)C)C6=C7C(C(=O)N(C7)C8C(=O)NC(=O)CC8)=CC=C6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.