Shopping Cart

Your shopping cart is currently empty

SUN B8155

Name: SUN B8155
Brand: TargetMol
SKU: T23406
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T23406Cas No. 345893-91-6

Alias SUN-B 8155

SUN B8155 is a calcitonin (CT) receptor agonist that selectively mimics the biological effects of calcitonin and induces cAMP formation in cells expressing recombinant human CT receptor.

SUN B8155

Copy Product Info

😃Good

Purity: 99.99%

Catalog No. T23406Alias SUN-B 8155Cas No. 345893-91-6

SUN B8155 is a calcitonin (CT) receptor agonist that selectively mimics the biological effects of calcitonin and induces cAMP formation in cells expressing recombinant human CT receptor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.99%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SUN B8155 is a calcitonin (CT) receptor agonist that selectively mimics the biological effects of calcitonin and induces cAMP formation in cells expressing recombinant human CT receptor.
Targets&IC50	cAMP:21 μM (EC50)
In vitro	SUN B8155 (1-1000 μM, 1 hr treatment) promoted intracellular cAMP production in a concentration-dependent manner in T47D cells, with cAMP levels increasing approximately 42-fold at the highest concentration. The compound also increased cAMP production in the UMR106-06 cell line derived from rat osteogenic sarcoma. In CHO/hPTHR or CHO parental cells, SUN B8155 was unable to trigger cAMP production. However, in CHO/hCTR cells, SUN B8155 significantly enhanced cAMP generation in a concentration-dependent manner with an EC50 of 21 μM. [1]
In vivo	Intraperitoneal injection of SUN B8155 (100 mg/kg) resulted in a significant decrease in serum calcium concentration of approximately 9% at 30 minutes post-dose.[1]
Synonyms	SUN-B 8155

Chemical Properties

Molecular Weight	273.29
Formula	C₁₄H₁₅N₃O₃
Cas No.	345893-91-6
Smiles	O=C1C=C(C(=C(O)N1O)C(=NC=2C=CC=CC2N)C)C
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (292.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (12.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6591 mL	18.2956 mL	36.5912 mL	182.9558 mL
5 mM	0.7318 mL	3.6591 mL	7.3182 mL	36.5912 mL
10 mM	0.3659 mL	1.8296 mL	3.6591 mL	18.2956 mL
20 mM	0.1830 mL	0.9148 mL	1.8296 mL	9.1478 mL
50 mM	0.0732 mL	0.3659 mL	0.7318 mL	3.6591 mL
100 mM	0.0366 mL	0.1830 mL	0.3659 mL	1.8296 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc