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SUN B8155

Name: SUN B8155
Brand: TargetMol
SKU: T23406
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23406Cas No. 345893-91-6

Alias SUN-B 8155

SUN B8155 is a calcitonin (CT) receptor agonist that selectively mimics the biological effects of calcitonin and induces cAMP formation in cells expressing recombinant human CT receptor.

SUN B8155

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Purity: 99.38%

Catalog No. T23406Alias SUN-B 8155Cas No. 345893-91-6

SUN B8155 is a calcitonin (CT) receptor agonist that selectively mimics the biological effects of calcitonin and induces cAMP formation in cells expressing recombinant human CT receptor.

Pack Size	Price	Availability	Quantity
2 mg	$149	In Stock

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Purity:99.38%

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Product Introduction

Bioactivity

Description	SUN B8155 is a calcitonin (CT) receptor agonist that selectively mimics the biological effects of calcitonin and induces cAMP formation in cells expressing recombinant human CT receptor.
Targets&IC50	cAMP:21 μM (EC50)
In vitro	SUN B8155 (1-1000 μM, 1 hr treatment) promoted intracellular cAMP production in a concentration-dependent manner in T47D cells, with cAMP levels increasing approximately 42-fold at the highest concentration. The compound also increased cAMP production in the UMR106-06 cell line derived from rat osteogenic sarcoma. In CHO/hPTHR or CHO parental cells, SUN B8155 was unable to trigger cAMP production. However, in CHO/hCTR cells, SUN B8155 significantly enhanced cAMP generation in a concentration-dependent manner with an EC50 of 21 μM. [1]
In vivo	Intraperitoneal injection of SUN B8155 (100 mg/kg) resulted in a significant decrease in serum calcium concentration of approximately 9% at 30 minutes post-dose.[1]
Synonyms	SUN-B 8155

Chemical Properties

Molecular Weight	273.29
Formula	C₁₄H₁₅N₃O₃
Cas No.	345893-91-6
Smiles	O=C1C=C(C(=C(O)N1O)C(=NC=2C=CC=CC2N)C)C
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (292.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6591 mL	18.2956 mL	36.5912 mL	182.9558 mL
5 mM	0.7318 mL	3.6591 mL	7.3182 mL	36.5912 mL
10 mM	0.3659 mL	1.8296 mL	3.6591 mL	18.2956 mL
20 mM	0.1830 mL	0.9148 mL	1.8296 mL	9.1478 mL
50 mM	0.0732 mL	0.3659 mL	0.7318 mL	3.6591 mL
100 mM	0.0366 mL	0.1830 mL	0.3659 mL	1.8296 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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