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Anti-PDE4D Polyclonal Antibody

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Catalog No. TMAB-10112

Anti-PDE4D Polyclonal Antibody is a Rabbit antibody targeting PDE4D. Anti-PDE4D Polyclonal Antibody can be used in WB,FCM.

Anti-PDE4D Polyclonal Antibody

Anti-PDE4D Polyclonal Antibody

😃Good
Catalog No. TMAB-10112
Anti-PDE4D Polyclonal Antibody is a Rabbit antibody targeting PDE4D. Anti-PDE4D Polyclonal Antibody can be used in WB,FCM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2217-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5297-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-PDE4D Polyclonal Antibody is a Rabbit antibody targeting PDE4D. Anti-PDE4D Polyclonal Antibody can be used in WB,FCM.
Ig Type
IgG
Reactivity
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Horse,Rabbit)
Application
WB
FCM
Recommended Dose
WB: 1:500-2000; FCM: 1μg/Test
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome.
Tissue SpecificityWidespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundCyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprise of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human PDE4D
Antigen Species
Human
Gene Name
PDE4D
Gene ID
5144
Protein Name
cAMP-specific 3', 5'-cyclic phosphodiesterase 4D
Uniprot ID
Q08499
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Chemical Properties
Molecular WeightTheoretical: 90 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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