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Niceritrol
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Catalog No. T19861Cas No. 5868-05-3
Alias Perycit, Cardiolipol, Bufor
Niceritrol (Cardiolipol) is a niacin ester that reduces cholesterol and triglycerides in total plasma and in the VLD and LD lipoprotein fractions.
Niceritrol
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Purity: 97.02%
Catalog No. T19861Alias Perycit, Cardiolipol, BuforCas No. 5868-05-3
Niceritrol (Cardiolipol) is a niacin ester that reduces cholesterol and triglycerides in total plasma and in the VLD and LD lipoprotein fractions.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $55 | In Stock | In Stock | |
| 2 mg | $77 | In Stock | In Stock | |
| 5 mg | $111 | In Stock | In Stock | |
| 10 mg | $158 | In Stock | In Stock | |
| 25 mg | $283 | In Stock | In Stock | |
| 50 mg | $426 | In Stock | In Stock | |
| 100 mg | $629 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $153 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.02%
Appearance:Solid
Color:White
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Product Introduction
Niceritrol AI Summary
Niceritrol exhibits moderate liver toxicity, evidenced by a 5.0% incidence rate during clinical trials and elevated serum activity levels of ALT, AST, or alkaline phosphatase. However, no acute liver toxicity, severe hepatitis, chronic liver disease, or other severe liver conditions were observed. This compound has demonstrated efficacy in inhibiting the entry of the Ebola virus with an AC50 value of 2238.7 nM observed in the green channel assay. Additionally, it showcases potential antiviral activity against SARS-CoV-2, displaying a 46.14% inhibition of virus-induced cytotoxicity in Caco-2 cells at 10 µM after 48 hours. It also inhibits the SARS-CoV-2 3CL-Pro protease by 8.673% at 20 µM and 0.44% inhibition of virus-induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours. Furthermore, Niceritrol shows inhibition of human HDAC6 enzyme activity with 7.98% inhibition using a commercial peptide substrate..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Niceritrol (Cardiolipol) is a niacin ester that reduces cholesterol and triglycerides in total plasma and in the VLD and LD lipoprotein fractions. |
| Synonyms | Perycit, Cardiolipol, Bufor |
| Molecular Weight | 556.52 |
| Formula | C29H24N4O8 |
| Cas No. | 5868-05-3 |
| Smiles | C(COC(=O)C=1C=CC=NC1)(COC(=O)C=2C=CC=NC2)(COC(=O)C=3C=CC=NC3)COC(=O)C=4C=CC=NC4 |
| Relative Density. | 1.347g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12 mg/mL (21.56 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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