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Adrenosterone

Name: Adrenosterone
Brand: TargetMol
SKU: T2207
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2207Cas No. 382-45-6

Alias Reichstein's substance G, 11-oxoandrostenedione, 11-ketoandrostenedione

Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.

Adrenosterone

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Purity: 98.29%

Catalog No. T2207Alias Reichstein's substance G, 11-oxoandrostenedione, 11-ketoandrostenedioneCas No. 382-45-6

Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$35	In Stock	In Stock
500 mg	$73	In Stock	In Stock
1 g	$108	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.29%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Adrenosterone AI Summary

Adrenosterone displays a range of bioactivities across different biological systems. In rats, it shows anabolic and androgenic activity, increasing the levator ani muscle weight and enlarging the ventral prostate and seminal vesicle, respectively, with an anabolic to androgenic activity ratio of 1.1. The compound has a lipophilicity value (LogP) of 3.75. In various biochemical assays, Adrenosterone enhances the expression of the SMN2 splice variant (potency: 1258.9 nM), inhibits AmpC Beta-Lactamase (potency: 22387.2 nM), DNA Polymerase Beta (potency: 4466.8 nM), alpha-syn (potency: 5623.4 nM), GLP-1 receptor (inverse agonist, potency: 12589.3 nM), USP1/UAF1 (potency: 89125.1 nM), and MBNL1-poly(CUG) RNA binding (potency: 891.3 nM). It also affects HP1-beta Chromodomain interactions with methylated histone tails (potency: 100000.0 nM) and induces DNA re-replication in MCF 10a normal breast cells (potency: 5173.5 nM). Regarding its antiviral activity, Adrenosterone demonstrates inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, although with relatively low potency (inhibition rates of 0.15% and 0.05% respectively). It also exhibits SARS-CoV-2 3CL-Pro protease inhibition activity at 20µM, with an inhibition percentage of 10.66%. The compound has a permeability value (Peff) of 6.05 x 10^-6 cm/s in the PAMPA-BBB penetration assay, indicating its potential to cross the blood-brain barrier. Inhibition of human HDAC6 enzymatic activity by Adrenosterone is mixed, with a slight decrease (-8.56%) in activity with a commercial peptide substrate and a minor increase (1.32%) using a custom peptide substrate, suggesting moderate bioactivity on human HDAC6..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.
Synonyms	Reichstein's substance G, 11-oxoandrostenedione, 11-ketoandrostenedione

Chemical Properties

Molecular Weight	300.39
Formula	C₁₉H₂₄O₃
Cas No.	382-45-6
Smiles	CC12CC(=O)C3C(CCC4=CC(=O)CCC34C)C1CCC2=O
Relative Density.	1.18g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (83.23 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3290 mL	16.6450 mL	33.2901 mL	166.4503 mL
5 mM	0.6658 mL	3.3290 mL	6.6580 mL	33.2901 mL
10 mM	0.3329 mL	1.6645 mL	3.3290 mL	16.6450 mL
20 mM	0.1665 mL	0.8323 mL	1.6645 mL	8.3225 mL
50 mM	0.0666 mL	0.3329 mL	0.6658 mL	3.3290 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc