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Cevimeline hydrochloride

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Catalog No. T20131Cas No. 107220-28-0
Alias Cevimeline HCl, AF102B hydrochloride, AF 102B hydrochloride

Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine that functions as a selective, orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride effectively stimulating exocrine secretion from salivary glands and thereby serving as a clinically relevant sialogogue for the treatment of xerostomia, while its demonstrated ability to cross the blood–brain barrier supports its utility in central and peripheral cholinergic signaling studies and translational neuropharmacological investigations.

Cevimeline hydrochloride
Other Forms of Cevimeline hydrochloride:

Cevimeline hydrochloride

😃Good
Catalog No. T20131Alias Cevimeline HCl, AF102B hydrochloride, AF 102B hydrochlorideCas No. 107220-28-0
Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine that functions as a selective, orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride effectively stimulating exocrine secretion from salivary glands and thereby serving as a clinically relevant sialogogue for the treatment of xerostomia, while its demonstrated ability to cross the blood–brain barrier supports its utility in central and peripheral cholinergic signaling studies and translational neuropharmacological investigations.
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2 mg$59-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine that functions as a selective, orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride effectively stimulating exocrine secretion from salivary glands and thereby serving as a clinically relevant sialogogue for the treatment of xerostomia, while its demonstrated ability to cross the blood–brain barrier supports its utility in central and peripheral cholinergic signaling studies and translational neuropharmacological investigations.
SynonymsCevimeline HCl, AF102B hydrochloride, AF 102B hydrochloride
Chemical Properties
Molecular Weight235.77
FormulaC10H18ClOS
Cas No.107220-28-0
SmilesC[C@@H]1O[C@@]2([C@H]3CCN(C2)CC3)CS1.Cl
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: Soluble
H2O: 40 mg/mL (169.66 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM4.2414 mL21.2071 mL42.4142 mL212.0711 mL
5 mM0.8483 mL4.2414 mL8.4828 mL42.4142 mL
10 mM0.4241 mL2.1207 mL4.2414 mL21.2071 mL
20 mM0.2121 mL1.0604 mL2.1207 mL10.6036 mL
50 mM0.0848 mL0.4241 mL0.8483 mL4.2414 mL
100 mM0.0424 mL0.2121 mL0.4241 mL2.1207 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

EvoxacCevimeline HydrochlorideCevimeline hydrochloride
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