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Cevimeline hydrochloride

Name: Cevimeline hydrochloride
Brand: TargetMol
SKU: T20131
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20131Cas No. 107220-28-0

Alias Cevimeline HCl, AF102B hydrochloride, AF 102B hydrochloride

Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine that functions as a selective, orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride effectively stimulating exocrine secretion from salivary glands and thereby serving as a clinically relevant sialogogue for the treatment of xerostomia, while its demonstrated ability to cross the blood–brain barrier supports its utility in central and peripheral cholinergic signaling studies and translational neuropharmacological investigations.

Cevimeline hydrochloride

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Catalog No. T20131Alias Cevimeline HCl, AF102B hydrochloride, AF 102B hydrochlorideCas No. 107220-28-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$59	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine that functions as a selective, orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride effectively stimulating exocrine secretion from salivary glands and thereby serving as a clinically relevant sialogogue for the treatment of xerostomia, while its demonstrated ability to cross the blood–brain barrier supports its utility in central and peripheral cholinergic signaling studies and translational neuropharmacological investigations.
In vitro	In digested parotid gland cells, Cevimeline hydrochloride (0.1-100 μM) induced a concentration-dependent increase in intracellular Ca2+ triggering exocytosis [1].
In vivo	In male Wistar rats, intraperitoneal (i.p.) injection of Cevimeline hydrochloride (0.008-0.016 mg/kg) induces long-lasting salivation and increases parotid gland blood flow. Furthermore, Cevimeline hydrochloride inhibits water intake induced by Angiotensin II (AngII) [1][2][5].
Synonyms	Cevimeline HCl, AF102B hydrochloride, AF 102B hydrochloride

Chemical Properties

Molecular Weight	235.77
Formula	C₁₀H₁₈ClOS
Cas No.	107220-28-0
Smiles	C[C@@H]1O[C@@]2([C@H]3CCN(C2)CC3)CS1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: Soluble

H2O: 40 mg/mL (169.66 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.2414 mL	21.2071 mL	42.4142 mL	212.0711 mL
5 mM	0.8483 mL	4.2414 mL	8.4828 mL	42.4142 mL
10 mM	0.4241 mL	2.1207 mL	4.2414 mL	21.2071 mL
20 mM	0.2121 mL	1.0604 mL	2.1207 mL	10.6036 mL
50 mM	0.0848 mL	0.4241 mL	0.8483 mL	4.2414 mL
100 mM	0.0424 mL	0.2121 mL	0.4241 mL	2.1207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc