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Anti-MMP-2 Antibody (3D181)
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Catalog No. TMAY-00229
Alias MMP-2, matrix metallopeptidase 2, GelA, Clg4a
Anti-MMP-2 Antibody (3D181) is a Mouse antibody targeting MMP-2. Anti-MMP-2 Antibody (3D181) can be used in ELISA,FCM.
Anti-MMP-2 Antibody (3D181)
Anti-MMP-2 Antibody (3D181)
😃Good
Catalog No. TMAY-00229Alias MMP-2, matrix metallopeptidase 2, GelA, Clg4a
Anti-MMP-2 Antibody (3D181) is a Mouse antibody targeting MMP-2. Anti-MMP-2 Antibody (3D181) can be used in ELISA,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $69 | 7-10 days | |
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA, FCM Reactivity: Human |
| Alias | MMP-2, matrix metallopeptidase 2, GelA, Clg4a |
| Ig Type | Mouse IgG2a |
| Clone | 3D181 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human MMP2 expression on MG63 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human MMP2, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | ELISA,FCM |
| Recommended Dose | ELISA: 1:5000-1:10000; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MMP-2 (rh MMP-2; TMPY-01477; NP_004521.1; Met 1-Cys660). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0 |
| Research Background | Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human MMP-2 protein (TMPY-01477) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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