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Danicopan

Name: Danicopan
Brand: TargetMol
SKU: T8509
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8509Cas No. 1903768-17-1

Alias ACH-4471

Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

Danicopan

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Purity: 99.94%

Catalog No. T8509Alias ACH-4471Cas No. 1903768-17-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
2 mg	$138	In Stock	In Stock
5 mg	$226	In Stock	In Stock
10 mg	$345	In Stock	In Stock
25 mg	$586	In Stock	In Stock
50 mg	$838	-	In Stock
100 mg	$1,160	-	In Stock
1 mL x 10 mM (in DMSO)	$289	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
Targets&IC50	FD:(kd)0.54 nM
In vitro	Danicopan (ACH-4471) inhibits the proteolytic activity of purified factor D and its natural substrate factor B binding to C3b, thereby blocking Bb fragment production in a dose-dependent manner, with an IC50 of 0.015 μM. Danicopan (ACH-4471) effectively inhibits hemolysis with IC50 values between 0.0040 μM and 0.027 μM (IC90 values between 0.015 μM and 0.11 μM).
Synonyms	ACH-4471

Chemical Properties

Molecular Weight	580.41
Formula	C₂₆H₂₃BrFN₇O₃
Cas No.	1903768-17-1
Smiles	CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)-c1cnc(C)nc1
Relative Density.	1.61 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (447.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7229 mL	8.6146 mL	17.2292 mL	86.1460 mL
5 mM	0.3446 mL	1.7229 mL	3.4458 mL	17.2292 mL
10 mM	0.1723 mL	0.8615 mL	1.7229 mL	8.6146 mL
20 mM	0.0861 mL	0.4307 mL	0.8615 mL	4.3073 mL
50 mM	0.0345 mL	0.1723 mL	0.3446 mL	1.7229 mL
100 mM	0.0172 mL	0.0861 mL	0.1723 mL	0.8615 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc