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Anti-Caspase-3 Antibody (3J336)

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Catalog No. TMAC-00583

Anti-Caspase-3 Antibody (3J336) is a Rabbit antibody targeting Caspase-3. Anti-Caspase-3 Antibody (3J336) can be used in WB,ICC/IF,IHC,IP,FCM.

Anti-Caspase-3 Antibody (3J336)

Anti-Caspase-3 Antibody (3J336)

😃Good
Catalog No. TMAC-00583
Anti-Caspase-3 Antibody (3J336) is a Rabbit antibody targeting Caspase-3. Anti-Caspase-3 Antibody (3J336) can be used in WB,ICC/IF,IHC,IP,FCM.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4967-10 days
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Product Introduction

Bioactivity
Description
Anti-Caspase-3 Antibody (3J336) is a Rabbit antibody targeting Caspase-3. Anti-Caspase-3 Antibody (3J336) can be used in WB,ICC/IF,IHC,IP,FCM.
Ig Type
IgG
Reactivity
Human,Mouse
Application
Recommended Dose
WB: 1:1000-5000; IHC: 1:50-200; ICC/IF: 1:50-100; FCM: 1:20-50
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundCaspase-3, also known as apopain, SCA-1, Yama and CPP32, is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp175-Ser176 to produce the p11 subunit and the p20 peptide. Subsequently, the p20 peptide is cleaved at Asp28-Ser29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 subunits. At the onset of apoptosis, caspase-3 proteolytically cleaves PARP at an Asp216-Gly217 bond. During the execution of the apoptotic cascade, activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6, -7 and -9. The human caspase-3 gene encodes a cytoplasmic protein that is highly expressed in lung, spleen, heart, liver, kidney and cells of the immune system.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
48658
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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