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CB1R antagonist 1

Name: CB1R antagonist 1
Brand: TargetMol
SKU: T61989
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T61989Cas No. 334668-69-8

CB1R antagonist 1 is a potent CB1R antagonist that can be used to study diseases related to the nervous system.

CB1R antagonist 1

🥰Excellent

Purity: 99.65%

Catalog No. T61989Cas No. 334668-69-8

CB1R antagonist 1 is a potent CB1R antagonist that can be used to study diseases related to the nervous system.

Pack Size	Price	Availability
5 mg	$68	In Stock
10 mg	$118	In Stock
25 mg	$198	In Stock
50 mg	$293	In Stock
100 mg	$438	In Stock

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Batch Information

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Purity:99.65%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	CB1R antagonist 1 is a potent CB1R antagonist that can be used to study diseases related to the nervous system.
Targets&IC50	CB1 receptor (human):10 uM (EC50), CB1 receptor (human):4.2 uM
In vitro	CB1R antagonist 1 exhibits cannabinoid-1 receptor (CB1R) activity with an IC50 value of 4.2 μM and an EC50 value greater than 10 μM [1].

Chemical Properties

Molecular Weight	404.45
Formula	C₁₈H₂₃F₃N₂O₃S
Cas No.	334668-69-8
Smiles	S(=O)(=O)(C1=CC(C(F)(F)F)=CC=C1)N2CCN(C(=O)C3CCCCC3)CC2
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (197.80 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4725 mL	12.3625 mL	24.7249 mL	123.6247 mL
5 mM	0.4945 mL	2.4725 mL	4.9450 mL	24.7249 mL
10 mM	0.2472 mL	1.2362 mL	2.4725 mL	12.3625 mL
20 mM	0.1236 mL	0.6181 mL	1.2362 mL	6.1812 mL
50 mM	0.0494 mL	0.2472 mL	0.4945 mL	2.4725 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc