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CB1R antagonist 1

Name: CB1R antagonist 1
Brand: TargetMol
SKU: T61989
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61989Cas No. 334668-69-8

CB1R antagonist 1 is a potent CB1R antagonist that can be used to study diseases related to the nervous system.

CB1R antagonist 1

😃Good

Purity: 99.65%

Catalog No. T61989Cas No. 334668-69-8

CB1R antagonist 1 is a potent CB1R antagonist that can be used to study diseases related to the nervous system.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$68	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$293	In Stock	In Stock
100 mg	$438	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	CB1R antagonist 1 is a potent CB1R antagonist that can be used to study diseases related to the nervous system.
Targets&IC50	CB1 receptor (human):10 uM (EC50), CB1 receptor (human):4.2 uM
In vitro	CB1R antagonist 1 exhibits cannabinoid-1 receptor (CB1R) activity with an IC50 value of 4.2 μM and an EC50 value greater than 10 μM [1].

Chemical Properties

Molecular Weight	404.45
Formula	C₁₈H₂₃F₃N₂O₃S
Cas No.	334668-69-8
Smiles	S(=O)(=O)(C1=CC(C(F)(F)F)=CC=C1)N2CCN(C(=O)C3CCCCC3)CC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (197.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4725 mL	12.3625 mL	24.7249 mL	123.6247 mL
5 mM	0.4945 mL	2.4725 mL	4.9450 mL	24.7249 mL
10 mM	0.2472 mL	1.2362 mL	2.4725 mL	12.3625 mL
20 mM	0.1236 mL	0.6181 mL	1.2362 mL	6.1812 mL
50 mM	0.0494 mL	0.2472 mL	0.4945 mL	2.4725 mL
100 mM	0.0247 mL	0.1236 mL	0.2472 mL	1.2362 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc