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1,7-Diphenyl-4-hepten-3-one is a compound isolated from Alpinia officinarum, which activates the Nrf2 pathway to suppress pyroptosis. It alleviates cognitive impairment and pathological damage in APP/PS1 mice and prevents oxidative stress damage while reducing levels of pyroptosis-related proteins. 1,7-Diphenyl-4-hepten-3-one enhances Aβ-induced proliferation in HT22 cells and can be used in Alzheimer’s disease research.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $689 | - | In Stock | |
| 5 mg | $1,487 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $1,798 | Inquiry | Inquiry |
| Description | 1,7-Diphenyl-4-hepten-3-one is a compound isolated from Alpinia officinarum, which activates the Nrf2 pathway to suppress pyroptosis. It alleviates cognitive impairment and pathological damage in APP/PS1 mice and prevents oxidative stress damage while reducing levels of pyroptosis-related proteins. 1,7-Diphenyl-4-hepten-3-one enhances Aβ-induced proliferation in HT22 cells and can be used in Alzheimer’s disease research. |
| In vitro | 1,7-Diphenyl-4-hepten-3-one prevents oxidative stress damage and reduces the levels of pyrogenic proteins. 1,7-Diphenyl-4-hepten-3-one improves Aβ-induced proliferation of HT22 cells and reduces the level of pyroxy-associated proteins. [1] |
| In vivo | 1,7-Diphenyl-4-hepten-3-one can alleviate AD-like pathology by activating Nrf2 pathway to inhibit pyrodeath. [1] |
| Molecular Weight | 264.36 |
| Formula | C19H20O |
| Cas No. | 79559-59-4 |
| Smiles | O=C(C=CCCC=1C=CC=CC1)CCC=2C=CC=CC2 |
| Relative Density. | 1.031 g/cm3 (Predicted) |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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