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Semicarbazide hydrochloride

Name: Semicarbazide hydrochloride
Brand: TargetMol
SKU: T1732
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1732Cas No. 563-41-7

Alias Aminourea hydrochloride

Semicarbazide hydrochloride is a urea derivative that binds to copper or iron in cells to produce antiviral, anti-infective and anti-tumor effects.

Semicarbazide hydrochloride

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Purity: 99.52%

Catalog No. T1732Alias Aminourea hydrochlorideCas No. 563-41-7

Semicarbazide hydrochloride is a urea derivative that binds to copper or iron in cells to produce antiviral, anti-infective and anti-tumor effects.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Semicarbazide hydrochloride AI Summary

Semicarbazide hydrochloride demonstrates bioactivity across a range of assays targeting various molecular entities, including modulation of splicing, interaction with histone proteins, DNA replication, and enzymatic inhibition. It is potent in inhibiting key proteins such as lamin A splicing, the JMJD2A-Tudor domain, G9a histone lysine methyltransferase, HP1-beta chromodomain, mammalian selenoprotein thioredoxin reductase 1, Polymerase Iota, Polymerase Eta, and Human Apurinic/apyrimidinic Endonuclease 1. Furthermore, Semicarbazide hydrochloride shows efficacy in inducing synthetic lethality in tumor cells and acts as a small molecule agonist of the antioxidant response element signaling pathway..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Semicarbazide hydrochloride is a urea derivative that binds to copper or iron in cells to produce antiviral, anti-infective and anti-tumor effects.
Synonyms	Aminourea hydrochloride

Chemical Properties

Molecular Weight	111.53
Formula	CH₆ClN₃O
Cas No.	563-41-7
Smiles	Cl.NNC(N)=O
Relative Density.	1.2908 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (246.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (17.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.9662 mL	44.8310 mL	89.6620 mL	448.3099 mL
5 mM	1.7932 mL	8.9662 mL	17.9324 mL	89.6620 mL
10 mM	0.8966 mL	4.4831 mL	8.9662 mL	44.8310 mL
20 mM	0.4483 mL	2.2415 mL	4.4831 mL	22.4155 mL
50 mM	0.1793 mL	0.8966 mL	1.7932 mL	8.9662 mL
100 mM	0.0897 mL	0.4483 mL	0.8966 mL	4.4831 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc