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GLP-1(32-36)amide

Name: GLP-1(32-36)amide
Brand: TargetMol
SKU: T37891
Rating: 4.5 (1 reviews)

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Catalog No. T37891Cas No. 1417302-71-6

GLP-1(32-36)amide is a pentapeptide compound derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has shown potential in inhibiting weight gain and regulating glucose metabolism in diabetic mice[1][2].

GLP-1(32-36)amide

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Catalog No. T37891Cas No. 1417302-71-6

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Product Introduction

Bioactivity

Description	GLP-1(32-36)amide is a pentapeptide compound derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has shown potential in inhibiting weight gain and regulating glucose metabolism in diabetic mice[1][2].
In vitro	GLP-1(32-36)amide (0.1-10 μM; 24 h) maintains cell viability and reduces apoptosis in INS‐1 cells treated with Streptozotocin (STZ; 1 μM) [2].
In vivo	GLP-1(32-36)amide (1 μmol/kg; i.p. once daily for 21 days) protects islets from damage, inhibits weight gain, and alleviates polydipsia symptoms in diabetic mice[2]. A single dose of GLP-1(32-36)amide (1 μmol/kg; i.p.) slightly reduces mean glucose levels 30 minutes post-glucose challenge in normal mice[2]. GLP-1(32-36)amide (50-70 nmol/kg/d; infusion for 12-16 weeks) prevents diet-induced obesity and hepatic steatosis in high-fat-fed mice[3]. Animal Model: Male KM mice (6-8 weeks; 18-22 g) injected with STZ[2].

Chemical Properties

Molecular Weight	570.74
Formula	C₂₅H₅₀N₁₀O₅
Cas No.	1417302-71-6
Smiles	CC(C)C[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Sequence	Leu-Val-Lys-Gly-Arg-NH2
Sequence Short	LVKGR

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (438.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7521 mL	8.7606 mL	17.5211 mL	87.6056 mL
5 mM	0.3504 mL	1.7521 mL	3.5042 mL	17.5211 mL
10 mM	0.1752 mL	0.8761 mL	1.7521 mL	8.7606 mL
20 mM	0.0876 mL	0.4380 mL	0.8761 mL	4.3803 mL
50 mM	0.0350 mL	0.1752 mL	0.3504 mL	1.7521 mL
100 mM	0.0175 mL	0.0876 mL	0.1752 mL	0.8761 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc