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PSB-0739
🥰Excellent
Catalog No. T23195Cas No. 1052087-90-7
Alias PSB0739
PSB-0739 Selective platelet P2Y12 receptor antagonist characterized by competitive binding and high affinity (Ki =24.9 nM) with antithrombotic and platelet aggregation modulating effects.
PSB-0739
🥰Excellent
Catalog No. T23195Alias PSB0739Cas No. 1052087-90-7
PSB-0739 Selective platelet P2Y12 receptor antagonist characterized by competitive binding and high affinity (Ki =24.9 nM) with antithrombotic and platelet aggregation modulating effects.
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Product Introduction
Bioactivity
Chemical Properties
| Description | PSB-0739 Selective platelet P2Y12 receptor antagonist characterized by competitive binding and high affinity (Ki =24.9 nM) with antithrombotic and platelet aggregation modulating effects. |
| Targets&IC50 | HIV-1 infection enhanced by SEVI:21.77 μM |
| In vitro | PSB-0739 inhibits the formation of semen-derived amyloid fibrils (SEVI), which enhance HIV-1 infection. It demonstrates direct anti-HIV activity with an IC₅₀ of 21.77 ± 5.15 μM, without significant cytotoxicity in HeLa cells at concentrations below 62.5 μM[1]. |
| In vivo | In rat models, PSB-0739 administered intrathecally (0.01–0.3 mg/kg) significantly reduced CFA-induced inflammatory pain and sciatic nerve ligation-induced neuropathic pain, with a minimal effective dose of 0.1 mg/kg. It also increased pain thresholds in the hot plate test, indicating analgesic effects. Additionally, PSB-0739 decreased the expression of pro-inflammatory cytokines such as IL-1β and TNF-α in inflamed tissues (paw and spinal cord), suggesting its mechanism involves inhibition of cytokine signaling both centrally and peripherally[2]. |
| Alias | PSB0739 |
| Molecular Weight | 609.54 |
| Formula | C26H17N3Na2O8S2 |
| Cas No. | 1052087-90-7 |
| Smiles | O=C1C2=C(C(C3=C(NC4=CC=C(C(S(=O)([O-])=O)=C4)NC5=CC=CC=C5)C=C(S(=O)([O-])=O)C(N)=C13)=O)C=CC=C2.[Na+].[Na+] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | H2O: 1.00 mg/mL (1.64 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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