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MK-7622

Name: MK-7622
Brand: TargetMol
SKU: T15942
Price: 183 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15942Cas No. 1227923-29-6

Alias M1 receptor modulator

MK-7622 (M1 receptor modulator) is a positive allosteric modulator of the muscarinic M1 receptor.

MK-7622

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Purity: 99.8%

Catalog No. T15942Alias M1 receptor modulatorCas No. 1227923-29-6

MK-7622 (M1 receptor modulator) is a positive allosteric modulator of the muscarinic M1 receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$45	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$183	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.8%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

MK-7622 AI Summary

MK-7622 acts as a positive allosteric modulator on the human muscarinic acetylcholine receptor M1, significantly enhancing acetylcholine-induced calcium mobilization with an EC50 of 63.0 nM. While it also exhibits agonist activity at the same receptor with an EC50 greater than 2000.0 nM, its maximum activity reaches 62% relative to control at 13 µM. The compound's competitive binding is notable, with a Ki value of 8.0 nM for displacing [3H]PT-1284 at the M1 receptor. Despite its functional benefits, MK-7622 presents toxicity in rats—unbound Cmax in plasma and brain can induce convulsions at 45 mg/kg. It has a low brain-to-plasma AUC ratio of 0.24 and a high brain-to-activity ratio of 33.0 at the same dosage. Additionally, it enhances IP1 accumulation in the striatum of C57BL/6 mice with drug uptake of 4.0 nM at doses ranging between 1 to 10 mg/kg. The compound demonstrates oral bioavailability, various pharmacokinetics in animal models, substrate activities at MDR1, and inhibitory activities against 5-LOX, PDE4, CYP2C9, human ERG, and SARS-CoV-2 with an IC50 greater than 20,000.0 nM. Furthermore, MK-7622 shows potential antialzheimer activity and significantly positive allosteric modulation of muscarinic acetylcholine receptors using a CCF4-AM dye-based assay, with an EC50 value of less than 100.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MK-7622 (M1 receptor modulator) is a positive allosteric modulator of the muscarinic M1 receptor.
Synonyms	M1 receptor modulator

Chemical Properties

Molecular Weight	399.48
Formula	C₂₅H₂₅N₃O₂
Cas No.	1227923-29-6
Smiles	Cc1ccc(Cc2cc3c(ncn([C@H]4CCCC[C@@H]4O)c3=O)c3ccccc23)cn1
Relative Density.	1.30 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (250.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5033 mL	12.5163 mL	25.0325 mL	125.1627 mL
5 mM	0.5007 mL	2.5033 mL	5.0065 mL	25.0325 mL
10 mM	0.2503 mL	1.2516 mL	2.5033 mL	12.5163 mL
20 mM	0.1252 mL	0.6258 mL	1.2516 mL	6.2581 mL
50 mM	0.0501 mL	0.2503 mL	0.5007 mL	2.5033 mL
100 mM	0.0250 mL	0.1252 mL	0.2503 mL	1.2516 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc