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Anti-Mast Cell Protease-1/MCPT-1 Antibody (8U785)
🥰Excellent
Catalog No. TMAY-03181
Anti-Mast Cell Protease-1/MCPT-1 Antibody (8U785) is a Rabbit antibody targeting Mast Cell Protease-1/MCPT-1. Anti-Mast Cell Protease-1/MCPT-1 Antibody (8U785) can be used in ELISA.
Anti-Mast Cell Protease-1/MCPT-1 Antibody (8U785)
Anti-Mast Cell Protease-1/MCPT-1 Antibody (8U785)
🥰Excellent
Catalog No. TMAY-03181
Anti-Mast Cell Protease-1/MCPT-1 Antibody (8U785) is a Rabbit antibody targeting Mast Cell Protease-1/MCPT-1. Anti-Mast Cell Protease-1/MCPT-1 Antibody (8U785) can be used in ELISA.
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Chemical Properties
| Description | Anti-Mast Cell Protease-1/MCPT-1 Antibody (8U785) is a Rabbit antibody targeting Mast Cell Protease-1/MCPT-1. Anti-Mast Cell Protease-1/MCPT-1 Antibody (8U785) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8U785 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse MCPT1 (rM MCPT1; TMPY-01027; NP_032596.1; Met 1-Lys 246). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared with nanograms of mMCP-2 are detected in peripheral blood during intestinal nematode infection. mMCP-1 isolated from serum is complexed with serpins and both the accumulation and the longevity of mMCP-1 in the blood is due to complex formation, protecting it from a pathway that rapidly clears mMCP-2, which is unable to form complexes with serpins. The mucosal mast cell (MMC) granule-specific beta-chymase, mouse mast cell protease-1 (mMCP-1), is released systemically into the bloodstream early in nematode infection before parasite-specific IgE responses develop and TGF-beta1 induces the constitutive release of mMCP-1 by homologs of MMC in vitro. Expression of mMCP-1 is largely restricted to intraepithelial MMC and is thought to play a role in the regulation of epithelial permeability. Its activation is completed by the removal of a two residue N-terminal propeptide by a dipeptidyl peptidase (Cathepsin C). MCPT-1 is upregulated in the intestine in response to nematode infection, or systemic mucosa in response to anaphylaxis. Like human α-chymase, MCPT-1 is capable of the conversion of angiotensin I to angiotensin II, which plays a key role in the regulation of arterial pressure. The intestinal inflammation associated with gastrointestinal helminths is partly mediated by mMCP-1. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse MCPT1 protein (TMPY-01027) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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