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Citalopram

Name: Citalopram
Brand: TargetMol
SKU: T20828
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20828Cas No. 59729-33-8

Alias Lu-10-171 Lu10-171, Lu 10-171, Cipram

Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enantiomer.Citalopram exhibits antidepressant activity and enhances serotonergic neurotransmission. It can be used to study Alzheimer's disease.

Citalopram

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Purity: 99.89%

Catalog No. T20828Alias Lu-10-171 Lu10-171, Lu 10-171, CipramCas No. 59729-33-8

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$41	In Stock	In Stock
100 mg	$64	In Stock	In Stock
500 mg	$153	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enantiomer.Citalopram exhibits antidepressant activity and enhances serotonergic neurotransmission. It can be used to study Alzheimer's disease.
In vitro	Citalopram exhibits concentration-dependent cytotoxicity when applied at concentrations ranging from 25 to 175 μM for 24 hours[4]. Specifically, at a concentration of 100 μM for 24 hours, Citalopram strongly downregulates the expression of MYBL2, BIRC5, BARD1, AURKA, CCNA2, and CCNE1 in B104 cells[4].
In vivo	Administered via intraperitoneal injection at doses ranging from 5 to 40 mg/kg, Citalopram reduces immobility time in DBA/2J mice but does not elicit a similar effect in C57BL/6J mice[3].
Synonyms	Lu-10-171 Lu10-171, Lu 10-171, Cipram

Chemical Properties

Molecular Weight	324.39
Formula	C₂₀H₂₁FN₂O
Cas No.	59729-33-8
Smiles	CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (123.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (6.17 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0827 mL	15.4135 mL	30.8271 mL	154.1355 mL
5 mM	0.6165 mL	3.0827 mL	6.1654 mL	30.8271 mL
10 mM	0.3083 mL	1.5414 mL	3.0827 mL	15.4135 mL
20 mM	0.1541 mL	0.7707 mL	1.5414 mL	7.7068 mL
50 mM	0.0617 mL	0.3083 mL	0.6165 mL	3.0827 mL
100 mM	0.0308 mL	0.1541 mL	0.3083 mL	1.5414 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc