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MRZ 2-514

Name: MRZ 2-514
Brand: TargetMol
SKU: T12110
Price: 88 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12110Cas No. 202808-11-5

Alias 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one

MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.

MRZ 2-514

🥰Excellent

Purity: 98.459%

Catalog No. T12110Alias 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-oneCas No. 202808-11-5

MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.

Pack Size	Price	Availability
1 mg	$88	In Stock
5 mg	$213	In Stock
10 mg	$347	In Stock
25 mg	$689	In Stock
50 mg	$1,160	In Stock
100 mg	$1,560	In Stock
1 mL x 10 mM (in DMSO)	$235	In Stock

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Batch Information

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Purity:98.459%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.
Targets&IC50	NMDA:33 μM (Ki), AMPA:72.7 μM
In vitro	MRZ 2-514 against peak AMPA-induced currents with IC50 values of 72.7 μM[1].
In vivo	In mice, MRZ 2-514 has anticonvulsive action in the MES model, and the effect is prolonged by probenecid[1].
Synonyms	8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one

Chemical Properties

Molecular Weight	308.09
Formula	C₁₁H₆BrN₃O₃
Cas No.	202808-11-5
Smiles	[O-][n+]1c2ccc(Br)cc2cc2c1c(=O)[nH][nH]c2=O
Relative Density.	2.07 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18.33 mg/mL (59.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2458 mL	16.2290 mL	32.4580 mL	162.2902 mL
5 mM	0.6492 mL	3.2458 mL	6.4916 mL	32.4580 mL
10 mM	0.3246 mL	1.6229 mL	3.2458 mL	16.2290 mL
20 mM	0.1623 mL	0.8115 mL	1.6229 mL	8.1145 mL
50 mM	0.0649 mL	0.3246 mL	0.6492 mL	3.2458 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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