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Phthalic acid

Name: Phthalic acid
Brand: TargetMol
SKU: T5603
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5603Cas No. 88-99-3

Alias 1,2-Benzenedioic acid

Phthalic acid (1,2-Benzenedioic acid) is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite.

Phthalic acid

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Purity: 99.31%

Catalog No. T5603Alias 1,2-Benzenedioic acidCas No. 88-99-3

Phthalic acid (1,2-Benzenedioic acid) is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$48	-	In Stock
10 g	$70	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.31%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Phthalic acid AI Summary

Phthalic acid has been studied for various biological activities and properties. It has a high intrinsic solubility in water, measured at 4130.0 μg/mL, and has been tested against multiple targets. It exhibits a high binding affinity toward the Lck SH2 domain with a Kd of 1700000.0 nM. The compound shows no significant inhibition of carbapenems-resistant Pseudomonas aeruginosa MSC15369 metallo-beta-lactamase IMP-1, with an IC50 of more than 100000.0 nM. Phthalic acid acts as an inhibitor of several proteins including Aldehyde Dehydrogenase 1 (ALDH1A1), lipid storage modulators, 15-human lipoxygenase (15-hLO), GCN5L2, BAZ2B, Rango, delayed-death inhibitors of the malarial parasite plastid, HP1-beta chromodomain interactions with methylated histone tails, peroxisome proliferator-activated receptor gamma signaling, estrogen receptor alpha signaling, and human tyrosyl-DNA phosphodiesterase 1 (TDP1), demonstrating potencies ranging from 65.1 nM to 100000.0 nM. It also shows antihemorrhagic activity, with an IC50 of 100.0 nM against Protobothrops flavoviridis venom-induced hemorrhagic lesion formation in mice. The dissociation constant (pKa) of this compound is 2.95. Additionally, Phthalic acid inhibits the uptake of estrone sulfate (E1S) in OATP-B-expressing HEK293 cells, with an inhibition activity level of 42.7%. Regarding tyrosinase inhibition, Phthalic acid exhibits mixed-type inhibition, inhibiting the oxygenase activity with L-DOPA substrate and the cresolase activity of mushroom tyrosinase with a Ki value of 100000.0 nM and an IC50 of 271790.0 nM. Interestingly, it also activates the cresolase activity with a Vmax of 14.47 μM/min and shows 11.0% activity relative to untreated control at concentrations up to 150 μM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Phthalic acid (1,2-Benzenedioic acid) is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite.
Synonyms	1,2-Benzenedioic acid

Chemical Properties

Molecular Weight	166.13
Formula	C₈H₆O₄
Cas No.	88-99-3
Smiles	OC(=O)C1=C(C=CC=C1)C(O)=O
Relative Density.	1.59 g/cm3 at 15℃

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (165.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0194 mL	30.0969 mL	60.1938 mL	300.9691 mL
5 mM	1.2039 mL	6.0194 mL	12.0388 mL	60.1938 mL
10 mM	0.6019 mL	3.0097 mL	6.0194 mL	30.0969 mL
20 mM	0.3010 mL	1.5048 mL	3.0097 mL	15.0485 mL
50 mM	0.1204 mL	0.6019 mL	1.2039 mL	6.0194 mL
100 mM	0.0602 mL	0.3010 mL	0.6019 mL	3.0097 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc