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Isoferulic acid

Name: Isoferulic acid
Brand: TargetMol
SKU: T2889
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2889Cas No. 537-73-5

Alias Isoferulate, Hesperetic acid, Hesperetate, 3-Hydroxy-4-methoxycinnamic acid

Isoferulic acid (Hesperetate) exhibits hypoglycemic properties.

Isoferulic acid

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Purity: 99.49%

Catalog No. T2889Alias Isoferulate, Hesperetic acid, Hesperetate, 3-Hydroxy-4-methoxycinnamic acidCas No. 537-73-5

Isoferulic acid (Hesperetate) exhibits hypoglycemic properties.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	-	In Stock
1 g	$64	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.49%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Isoferulic acid AI Summary

Isoferulic acid is a bioactive molecule that demonstrates a range of biological activities. It inhibits the diphenolase activity of mushroom tyrosinase at a concentration of 0.035 mM, with an inhibition of 7.9%, and shows an IC50 of 115,200.0 nM in a different mushroom tyrosinase inhibition assay. Although it exhibits antiproliferative activity against various cell lines including mouse B16-BL6, human HT1080, human A549, human HeLa, and mouse 26-L5 cells, its EC50 values are consistently greater than 515,000.0 nM, indicating low potency in cell proliferation inhibition. In terms of cytotoxicity, it shows an IC50 value greater than 10,000.0 nM against human HeLa cells and greater than 50,000.0 nM in anti-inflammatory assays involving mouse RAW264.7 cells. The compound inhibits hyaluronidase with an IC50 value greater than 2,000,000.0 nM and alpha-amylase with an IC50 value greater than 7,000,000.0 nM. It also exhibits antioxidant activities with an EC50 value greater than 250,000.0 nM in DPPH radical scavenging assays. Additionally, Isoferulic acid shows estrogenic activity, acting on the ERalpha receptor in human MVLN cells, achieving substantial luciferase reporter gene expression at concentrations of 20 and 100 μg/mL. In ion channel assays, it exhibits strong inhibition (98.5%) of the Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus laevis oocytes, with an antagonist IC50 value of 13,500.0 nM. The compound is also cytoprotective against H2O2-induced cytotoxicity in human EAhy926 cells, with an EC50 of 29,300.0 nM for protective effects. It exhibits antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms, with an IC50 value of less than 30,000.0 nM. Furthermore, Isoferulic acid shows varied bioactivities across several specific assays, including inhibition of Chronic Active B-Cell Receptor Signaling (6513.1 nM), ELG1-dependent DNA repair (25,918.5 nM), HP1-beta Chromodomain interactions (100,000.0 nM), acting as an agonist of gsp for Fibrous Dysplasia/McCune-Albright Syndrome (3981.1 nM), and inhibiting human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells in the presence of CPT (29,092.9 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isoferulic acid (Hesperetate) exhibits hypoglycemic properties.
Targets&IC50	α1-adrenoceptor:1.4 µM (EC50), β-endorphin:52.2 nM (EC50)
Synonyms	Isoferulate, Hesperetic acid, Hesperetate, 3-Hydroxy-4-methoxycinnamic acid

Chemical Properties

Molecular Weight	194.18
Formula	C₁₀H₁₀O₄
Cas No.	537-73-5
Smiles	COC1=C(O)C=C(\C=C\C(O)=O)C=C1
Relative Density.	1.0583 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (257.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1499 mL	25.7493 mL	51.4986 mL	257.4930 mL
5 mM	1.0300 mL	5.1499 mL	10.2997 mL	51.4986 mL
10 mM	0.5150 mL	2.5749 mL	5.1499 mL	25.7493 mL
20 mM	0.2575 mL	1.2875 mL	2.5749 mL	12.8747 mL
50 mM	0.1030 mL	0.5150 mL	1.0300 mL	5.1499 mL
100 mM	0.0515 mL	0.2575 mL	0.5150 mL	2.5749 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc