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para-Nitroblebbistatin

🥰Excellent
Catalog No. T12360Cas No. 1621326-32-6
Alias p-Nitroblebbistatin

para-Nitroblebbistatin is a non-cytotoxic, non-fluorescent, photostable, and specific inhibitor of myosin II. para-Nitroblebbistatin can be used to study the specific roles of myosin II in physiology, development, and cell biology.

para-Nitroblebbistatin

para-Nitroblebbistatin

🥰Excellent
Purity: 99.84%
Catalog No. T12360Alias p-NitroblebbistatinCas No. 1621326-32-6
para-Nitroblebbistatin is a non-cytotoxic, non-fluorescent, photostable, and specific inhibitor of myosin II. para-Nitroblebbistatin can be used to study the specific roles of myosin II in physiology, development, and cell biology.
Pack SizePriceAvailabilityQuantity
1 mg$89In Stock
5 mg$223In Stock
10 mg$333In Stock
25 mg$538In Stock
50 mg$732In Stock
100 mg$990In Stock
200 mg$1,330In Stock
1 mL x 10 mM (in DMSO)$227In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.84%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
para-Nitroblebbistatin is a non-cytotoxic, non-fluorescent, photostable, and specific inhibitor of myosin II. para-Nitroblebbistatin can be used to study the specific roles of myosin II in physiology, development, and cell biology.
In vitro
METHODS: HeLa cells were treated with para-Nitroblebbistatin (p-Nitroblebbistatin) (20 μM, 3 days) and the changes in cell number and death rate were tracked.
RESULTS para-Nitroblebbistatin effectively inhibited cytokinesis and had no effect on cell number and death rate. [1]
Synonymsp-Nitroblebbistatin
Chemical Properties
Molecular Weight337.33
FormulaC18H15N3O4
Cas No.1621326-32-6
SmilesCc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c1ccc(cc1)[N+]([O-])=O
Relative Density.1.47 g/cm3 (Predicted)
ColorOrange
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 11 mg/mL (32.61 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9645 mL14.8223 mL29.6446 mL148.2228 mL
5 mM0.5929 mL2.9645 mL5.9289 mL29.6446 mL
10 mM0.2964 mL1.4822 mL2.9645 mL14.8223 mL
20 mM0.1482 mL0.7411 mL1.4822 mL7.4111 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

para-NitroblebbistatinMyosin II
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