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Oxyresveratrol

Name: Oxyresveratrol
Brand: TargetMol
SKU: T3S1068
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3S1068Cas No. 29700-22-9

Alias trans-Oxyresveratrol, Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene

1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxidant activity, can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2.

Oxyresveratrol

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Purity: 99.98%

Catalog No. T3S1068Alias trans-Oxyresveratrol, Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbeneCas No. 29700-22-9

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$31	In Stock	In Stock
500 mg	$113	In Stock	In Stock
1 g	$179	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Oxyresveratrol AI Summary

Oxyresveratrol exhibits a wide range of bioactivities. It inhibits the ethoxyresorufin O-deethylation (EROD) activity in bacterial membranes expressing human cytochrome P450 enzymes 1A1, 1A2, and 1B1, with IC50 values of 15000.0 nM, 150000.0 nM, and 34000.0 nM, respectively, and shows selectivity for P450 1B1 over P450 1A1 and P450 1A2. Additionally, it demonstrates potent inhibitory activity against tyrosinase, with IC50 values ranging from 90.0 nM to 12700.0 nM and significant inhibition rates in various assays. Oxyresveratrol also inhibits COX enzymes, with IC50 values of 1400.0 nM for COX1 and 109000.0 nM for COX2. It displays inhibitory activity against Mycobacterium tuberculosis PtpA and PtpB enzymes and shows selectivity compared to other phosphatases. Furthermore, the compound inhibits the formation of amyloid beta 25-35 fibrils by 32.0% at 10 uM and exhibits antioxidant properties by scavenging multiple types of radicals. Inhibition of other enzymes includes human recombinant MMP2 with an IC50 of 27600.0 nM, porcine pancreatic lipase with an IC50 greater than 70000.0 nM, and human 5-lipoxygenase (5-LOX) with an IC50 of 18490.0 nM. It also acts as an allosteric modulator of the rat GABAA alpha1beta2gamma2S receptor, enhancing the GABA-induced chloride ion current at 100 uM. Oxyresveratrol shows inhibitory activity against quorum sensing in Pseudomonas aeruginosa and Chromobacterium violaceum, as well as antibacterial activity with varying MIC values against several bacterial strains. It inhibits Escherichia coli DHFR with an IC50 of 95700.0 nM and Ki of 31480.0 nM and exhibits antiviral activity against HSV-1 and HSV-2 in Vero cells with IC50 values around 20 ug/mL. Furthermore, the compound shows low cytotoxicity against human KB, NCI-H187, and BC cells, involvement in gene expression modulation, cellular response to stress, and inhibition of intracellular signaling and enzyme activities related to lipid storage and DNA repair mechanisms. It also demonstrates inhibitory effects on C-Myc/DDK-tagged human SYNJ1 and SYNJ2 in HEK293T cells with IC50 values of 6650.0 nM and <= 15900.0 nM, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxidant activity, can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2.
Targets&IC50	DPPH:28.9 μM
Synonyms	trans-Oxyresveratrol, Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene

Chemical Properties

Molecular Weight	244.24
Formula	C₁₄H₁₂O₄
Cas No.	29700-22-9
Smiles	C(=C/C1=C(O)C=C(O)C=C1)\C2=CC(O)=CC(O)=C2
Relative Density.	1.468 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 54.44 mg/mL (222.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0943 mL	20.4717 mL	40.9433 mL	204.7167 mL
5 mM	0.8189 mL	4.0943 mL	8.1887 mL	40.9433 mL
10 mM	0.4094 mL	2.0472 mL	4.0943 mL	20.4717 mL
20 mM	0.2047 mL	1.0236 mL	2.0472 mL	10.2358 mL
50 mM	0.0819 mL	0.4094 mL	0.8189 mL	4.0943 mL
100 mM	0.0409 mL	0.2047 mL	0.4094 mL	2.0472 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc