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(1R,2S)-VU0155041

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Catalog No. T13424Cas No. 1263273-14-8

(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.

(1R,2S)-VU0155041
Other Forms of (1R,2S)-VU0155041:

(1R,2S)-VU0155041

🥰Excellent
Purity: 98.85%
Catalog No. T13424Cas No. 1263273-14-8
(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.
Pack SizePriceAvailabilityQuantity
5 mg$32In Stock
10 mgPreferentialIn Stock
25 mgPreferentialIn Stock
1 mL x 10 mM (in DMSO)$31In Stock
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Batch Information

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Purity:98.85%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.
Targets&IC50
mGluR4 (rat):(EC50)2.35 μM
In vitro
(1R,2S)-VU0155041 is similar in potency with VU0155041 At both human and rat receptors (798 nM at human mGluR4 and 693 nM at rat mGluR4). (1R,2S)-VU0155041 (30 μM) induces concentration-dependent shifts in the baseline when examined in fold shift experiments using the thallium flux assay[1].
Chemical Properties
Molecular Weight316.18
FormulaC14H15Cl2NO3
Cas No.1263273-14-8
SmilesOC(=O)[C@@H]1CCCC[C@@H]1C(=O)Nc1cc(Cl)cc(Cl)c1
Relative Density.1.429 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 54 mg/mL (170.79 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1628 mL15.8138 mL31.6276 mL158.1378 mL
5 mM0.6326 mL3.1628 mL6.3255 mL31.6276 mL
10 mM0.3163 mL1.5814 mL3.1628 mL15.8138 mL
20 mM0.1581 mL0.7907 mL1.5814 mL7.9069 mL
50 mM0.0633 mL0.3163 mL0.6326 mL3.1628 mL
100 mM0.0316 mL0.1581 mL0.3163 mL1.5814 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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Keywords

VU-0155041VU0155041VU 0155041rat mGluR4mGluR4(1R,2S)-VU-0155041(1R,2S)VU0155041(1R,2S) VU0155041
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