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Anti-Phospho-NFATC4 (Ser168+Ser170) Polyclonal Antibody
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Catalog No. TMAB-11041
Anti-Phospho-NFATC4 (Ser168+Ser170) Polyclonal Antibody is a Rabbit antibody targeting Phospho-NFATC4 (Ser168+Ser170). Anti-Phospho-NFATC4 (Ser168+Ser170) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-NFATC4 (Ser168+Ser170) Polyclonal Antibody
Anti-Phospho-NFATC4 (Ser168+Ser170) Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-11041
Anti-Phospho-NFATC4 (Ser168+Ser170) Polyclonal Antibody is a Rabbit antibody targeting Phospho-NFATC4 (Ser168+Ser170). Anti-Phospho-NFATC4 (Ser168+Ser170) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-NFATC4 (Ser168+Ser170) Polyclonal Antibody is a Rabbit antibody targeting Phospho-NFATC4 (Ser168+Ser170). Anti-Phospho-NFATC4 (Ser168+Ser170) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded (mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (phospho-NFATC4 (Ser168+Ser170)) Polyclonal Antibody, Unconjugated (TMAB-11041) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 2. Paraformaldehyde-fixed, paraffin embedded (mouse lung); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (phospho-NFATC4 (Ser168+Ser170)) Polyclonal Antibody, Unconjugated (TMAB-11041) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 3. Paraformaldehyde-fixed, paraffin embedded (human tonsil); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (phospho-NFATC4 (Ser168+Ser170)) Polyclonal Antibody, Unconjugated (TMAB-11041) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
| Tissue Specificity | Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The product of this gene is a member of the nuclearfactors of activated T cells DNA-binding transcription complex.This complex consists of at least two components: a preexistingcytosolic component that translocates to the nucleus upon T cellreceptor (TCR) stimulation and an inducible nuclear component.Other members of this family of nuclear factors of activated Tcells also participate in the formation of this complex. Theproduct of this gene plays a role in the inducible expression ofcytokine genes in T cells, especially in the induction of the IL-2and IL-4. Alternatively spliced transcript variants encodingdifferent isoforms have been noted for this gene. [provided byRefSeq, Oct 2008]. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human NFATC4 around the phosphorylation site of Ser168 + Ser170 |
| Antigen Species | Human |
| Gene Name | NFATC4 |
| Gene ID | |
| Protein Name | Nuclear factor of activated T-cells, cytoplasmic 4 |
| Uniprot ID | |
| Function | Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. |
| Molecular Weight | Theoretical: 95 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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