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GLUT inhibitor-1

Name: GLUT inhibitor-1
Brand: TargetMol
SKU: T40083
Rating: 4.5 (1 reviews)

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Catalog No. T40083Cas No. 2421141-40-2

GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.

GLUT inhibitor-1

😃Good

Catalog No. T40083Cas No. 2421141-40-2

GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.

Pack Size	Price	Availability
5 mg	$648	Backorder
10 mg	$997	Backorder
25 mg	$1,990	Backorder
100 mg	Inquiry	Backorder

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Product Introduction

Bioactivity

Description	GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.
Targets&IC50	GLUT1:242 nM (IC50), GLUT3:179 nM (IC50)
In vivo	GLUT inhibitor-1 exhibits good oral pharmacokinetic parameters in mice and rats with oral Cmax values of 2525 and 1675 ng/mL, AUCs of 5890 and 6813 ng/mL, CLs of 40 and 37 mL/min/kg, Vdss of 1.70 and 4.51 L/Kg, t1/2s of 0.785 and 2.59h and Fs of 45.4% and 49.4%[1].

Chemical Properties

Molecular Weight	549.67
Formula	C₃₂H₃₅N₇O₂
Cas No.	2421141-40-2
Smiles	CC1(CC1)NC(=O)COc1cccc(c1)-c1nc2CCN(Cc2c(Nc2ccc(cc2)-c2cn[nH]c2)n1)C1CCC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (163.7 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8193 mL	9.0964 mL	18.1927 mL	90.9637 mL
5 mM	0.3639 mL	1.8193 mL	3.6385 mL	18.1927 mL
10 mM	0.1819 mL	0.9096 mL	1.8193 mL	9.0964 mL
20 mM	0.0910 mL	0.4548 mL	0.9096 mL	4.5482 mL
50 mM	0.0364 mL	0.1819 mL	0.3639 mL	1.8193 mL
100 mM	0.0182 mL	0.0910 mL	0.1819 mL	0.9096 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc