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GLUT inhibitor-1

Name: GLUT inhibitor-1
Brand: TargetMol
SKU: T40083
Rating: 4.5 (1 reviews)

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Catalog No. T40083Cas No. 2421141-40-2

GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.

GLUT inhibitor-1

😃Good

Catalog No. T40083Cas No. 2421141-40-2

GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$648	Inquiry	Inquiry
10 mg	$997	Inquiry	Inquiry
25 mg	$1,990	Inquiry	Inquiry
100 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	GLUT inhibitor-1 is an orally active GLUT inhibitor with IC50 s of 242 nM and 179 nM for GLUT1 and GLUT3. GLUT inhibitor-1 can be used in studies about cancers and autoimmune diseases.
Targets&IC50	GLUT3:179 nM (IC50), GLUT1:242 nM (IC50)
In vivo	GLUT inhibitor-1 exhibits good oral pharmacokinetic parameters in mice and rats with oral Cmax values of 2525 and 1675 ng/mL, AUCs of 5890 and 6813 ng/mL, CLs of 40 and 37 mL/min/kg, Vdss of 1.70 and 4.51 L/Kg, t1/2s of 0.785 and 2.59h and Fs of 45.4% and 49.4%[1].

Chemical Properties

Molecular Weight	549.67
Formula	C₃₂H₃₅N₇O₂
Cas No.	2421141-40-2
Smiles	CC1(CC1)NC(=O)COc1cccc(c1)-c1nc2CCN(Cc2c(Nc2ccc(cc2)-c2cn[nH]c2)n1)C1CCC1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (163.73 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8193 mL	9.0964 mL	18.1927 mL	90.9637 mL
5 mM	0.3639 mL	1.8193 mL	3.6385 mL	18.1927 mL
10 mM	0.1819 mL	0.9096 mL	1.8193 mL	9.0964 mL
20 mM	0.0910 mL	0.4548 mL	0.9096 mL	4.5482 mL
50 mM	0.0364 mL	0.1819 mL	0.3639 mL	1.8193 mL
100 mM	0.0182 mL	0.0910 mL	0.1819 mL	0.9096 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc