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MSDC-0602K

Catalog No. T38715 CAS 1314533-27-1

Synonyms: Azemiglitazone potassium

MSDC-0602K (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both individually and in combination with Liraglutide.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MSDC-0602K, CAS 1314533-27-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 55.00
5 mg	In stock	$ 143.00
10 mg	In stock	$ 228.00
25 mg	In stock	$ 463.00
50 mg	In stock	$ 738.00
100 mg	In stock	$ 987.00
500 mg	In stock	$ 1,980.00

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Purity: 99.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MSDC-0602K (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both individually and in combination with Liraglutide.
Targets&IC50	PPAR-γ:18.25 μM
In vivo	Diabetic db/db and MS-NASH mice are treated with MSDC-0602K by oral gavage, Liraglutide by s.c. injection, or combination MSDC-0602K + Liraglutide. This combination treatment may be an effective therapeutic strategy for diabetes and non-alcoholic steatohepatitis. Animal Model: Five-week-old male db/db mice on C57BL/6J background and age/sex-matched db/+ control mice [1] Dosage: 30 mg/kg MSDC-0602K; 0.2 mg/kg Liraglutide Administration: MSDC-0602K gavage daily, Liraglutide s.c. every other day, or combined MSDC-0602K+ Liraglutide Result: MSDC-0602K corrected glycemia and reduced insulinemia when given alone, or in combination with Liraglutide. However, MSDC-0602K + Liraglutide combination more significantly improved glucose tolerance and liver histology[1].

Synonyms	Azemiglitazone potassium
Molecular Weight	409.5
Formula	C19H16KNO5S
CAS No.	1314533-27-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhouji Chen, et al. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48. 2. Jerry R Colca, et al. MSDC-0602K, a metabolic modulator directed at the core pathology of non-alcoholic steatohepatitis. Expert Opin Investig Drugs. 2018 Jul;27(7):631-636. 3. Dakota R Kamm, et al. Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide. J Biol Chem. Jan-Jun 2021;296:100807.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library DNA Damage & Repair Compound Library Anti-Obesity Compound Library Nuclear Receptor Compound Library Mitochondria-Targeted Compound Library Bioactive Compounds Library Max Clinical Compound Library

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Related compounds with same targets

Mavodelpar free acid Tesaglitazar Daltroban Mavodelpar free acid hydrochloride Sulotroban Sulotroban potassium Cevoglitazar (S)-Coriolic acid

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Keywords

MSDC-0602K 1314533-27-1 DNA Damage/DNA Repair Metabolism PPAR Azemiglitazone potassium inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.