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Z-Asp-CH2-DCB

Name: Z-Asp-CH2-DCB
Brand: TargetMol
SKU: T13378
Rating: 4.5 (1 reviews)

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Catalog No. T13378Cas No. 153088-73-4

Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.

Z-Asp-CH2-DCB

😃Good

Catalog No. T13378Cas No. 153088-73-4

Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$38	Inquiry	Inquiry
25 mg	Preferential	Inquiry	Inquiry
50 mg	Preferential	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.
In vitro	Z-Asp-CH2-DCB (10-100 μM) dose-dependently inhibits the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng) PBMC, and suppresses the chemokines MCP-1, MIP-1α, and MIP-1β[1]. Additionally, Z-Asp-CH2-DCB reduces IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β production in TSST-1-activated PBMC to 10%, 36%, 25%, 10%, 11%, 25%, and 30%, respectively[1].
In vivo	SU5416-induced septal cell apoptosis prevented byZ-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks)[1].

Chemical Properties

Molecular Weight	454.26
Formula	C₂₀H₁₇Cl₂NO₇
Cas No.	153088-73-4
Smiles	OC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)COC(=O)c1c(Cl)cccc1Cl
Relative Density.	1.440 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95.4 mg/mL (210.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2014 mL	11.0069 mL	22.0138 mL	110.0691 mL
5 mM	0.4403 mL	2.2014 mL	4.4028 mL	22.0138 mL
10 mM	0.2201 mL	1.1007 mL	2.2014 mL	11.0069 mL
20 mM	0.1101 mL	0.5503 mL	1.1007 mL	5.5035 mL
50 mM	0.0440 mL	0.2201 mL	0.4403 mL	2.2014 mL
100 mM	0.0220 mL	0.1101 mL	0.2201 mL	1.1007 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc