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Z-Asp-CH2-DCB

Name: Z-Asp-CH2-DCB
Brand: TargetMol
SKU: T13378
Rating: 4.5 (1 reviews)

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Catalog No. T13378Cas No. 153088-73-4

Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.

Z-Asp-CH2-DCB

😃Good

Catalog No. T13378Cas No. 153088-73-4

Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$38	Inquiry	Inquiry
25 mg	Preferential	Backorder	Backorder
50 mg	Preferential	Backorder	Backorder

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Z-Asp-CH2-DCB is an irreversible inhibitor of broad-spectrum caspases.
In vitro	Z-Asp-CH2-DCB (10-100 μM) dose-dependently inhibits the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng) PBMC, and suppresses the chemokines MCP-1, MIP-1α, and MIP-1β[1]. Additionally, Z-Asp-CH2-DCB reduces IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β production in TSST-1-activated PBMC to 10%, 36%, 25%, 10%, 11%, 25%, and 30%, respectively[1].
In vivo	SU5416-induced septal cell apoptosis prevented byZ-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks)[1].

Chemical Properties

Molecular Weight	454.26
Formula	C₂₀H₁₇Cl₂NO₇
Cas No.	153088-73-4
Smiles	OC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)COC(=O)c1c(Cl)cccc1Cl
Relative Density.	1.440 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95.4 mg/mL (210.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2014 mL	11.0069 mL	22.0138 mL	110.0691 mL
5 mM	0.4403 mL	2.2014 mL	4.4028 mL	22.0138 mL
10 mM	0.2201 mL	1.1007 mL	2.2014 mL	11.0069 mL
20 mM	0.1101 mL	0.5503 mL	1.1007 mL	5.5035 mL
50 mM	0.0440 mL	0.2201 mL	0.4403 mL	2.2014 mL
100 mM	0.0220 mL	0.1101 mL	0.2201 mL	1.1007 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc