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Anti-Claudin 18.2 Antibody (2E598)
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Catalog No. TMAB-04422
Anti-Claudin 18.2 Antibody (2E598) is a Rabbit antibody targeting Claudin 18.2. Anti-Claudin 18.2 Antibody (2E598) can be used in IHC-P,IHC-Fr,IF.
Anti-Claudin 18.2 Antibody (2E598)
Anti-Claudin 18.2 Antibody (2E598)
😃Good
Catalog No. TMAB-04422
Anti-Claudin 18.2 Antibody (2E598) is a Rabbit antibody targeting Claudin 18.2. Anti-Claudin 18.2 Antibody (2E598) can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $472 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Antigen Details
Chemical Properties
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| Description | Anti-Claudin 18.2 Antibody (2E598) is a Rabbit antibody targeting Claudin 18.2. Anti-Claudin 18.2 Antibody (2E598) can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Clone | 2E598 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell junction > tight junction. Cell membrane. |
| Tissue Specificity | Concentrated at the cell-cell borders of epithelial cells. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (6). |
| Immunogen | KLH conjugated synthetic peptide: human Claudin-18.2 |
| Antigen Species | Human |
| Gene Name | CLDN18 |
| Gene ID | |
| Protein Name | Claudin-18 |
| Uniprot ID | |
| Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
| Molecular Weight | Theoretical: 28 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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