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Dihydroisotanshinone I
😃Good
Catalog No. TN1588Cas No. 20958-18-3
Dihydroisotanshinone I is a natural product isolated from the dried roots of Salvia miltiorrhiza, a traditional Chinese medicine, and exhibits various biological activities. Dihydroisotanshinone I alleviates menadione-induced liver injury through antioxidant effects such as scavenging free radicals and inhibiting lipid peroxidation; it also inhibits the migration of prostate cancer cells and induces cancer cell apoptosis.
Dihydroisotanshinone I
😃Good
Purity: 99.75%
Catalog No. TN1588Cas No. 20958-18-3
Dihydroisotanshinone I is a natural product isolated from the dried roots of Salvia miltiorrhiza, a traditional Chinese medicine, and exhibits various biological activities. Dihydroisotanshinone I alleviates menadione-induced liver injury through antioxidant effects such as scavenging free radicals and inhibiting lipid peroxidation; it also inhibits the migration of prostate cancer cells and induces cancer cell apoptosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $818 | - | In Stock | |
| 5 mg | $1,800 | - | In Stock | |
| 10 mg | $2,700 | - | In Stock | |
| 25 mg | $4,590 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.75%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Dihydroisotanshinone I is a natural product isolated from the dried roots of Salvia miltiorrhiza, a traditional Chinese medicine, and exhibits various biological activities. Dihydroisotanshinone I alleviates menadione-induced liver injury through antioxidant effects such as scavenging free radicals and inhibiting lipid peroxidation; it also inhibits the migration of prostate cancer cells and induces cancer cell apoptosis. |
| In vitro | Dihydroisotanshinone I induces cell cycle G1 arrest by inhibiting the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1 and SKP2, and suppresses the proliferation of human osteosarcoma 143B cells in a dose- and time-dependent manner. Dihydroisotanshinone I induces apoptosis via activating caspase-3, caspase-8, caspase-9 and cleaving PARP, and inhibits cell migration by down-regulating VCAM-1 and ICAM-1. |
| In vivo | In xenograft tumor models, Dihydroisotanshinone I inhibits the proliferation of Hela human cervical cancer cells. It enhances radiation-induced apoptosis and significantly inhibits proliferation in Hela cells mainly by prolonging radiation-induced G2/M arrest and reducing the expression levels of Bcl-XL, Bcl-2 and HPV E6 protein. |
| Molecular Weight | 278.31 |
| Formula | C18H14O3 |
| Cas No. | 20958-18-3 |
| Smiles | O=C1C=2OCC(C2C(=O)C3=CC=C4C(C=CC=C4C)=C13)C |
| Relative Density. | 1.32g/cm3 |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.00 mg/mL (17.97 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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